Neonatal hypoxia ischaemia: mechanisms, models, and therapeutic challenges

LJ Millar, L Shi, A Hoerder-Suabedissen… - Frontiers in cellular …, 2017 - frontiersin.org
Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

Therapeutic hypothermia for mild neonatal encephalopathy: a systematic review and meta-analysis

U Kariholu, P Montaldo, T Markati, PJ Lally… - Archives of Disease in …, 2020 - fn.bmj.com
Objectives To examine if therapeutic hypothermia reduces the composite outcome of death,
moderate or severe disability at 18 months or more after mild neonatal encephalopathy …

Prospective research in infants with mild encephalopathy identified in the first six hours of life: neurodevelopmental outcomes at 18–22 months

LF Chalak, KA Nguyen, C Prempunpong, R Heyne… - Pediatric …, 2018 - nature.com
Background Studies of early childhood outcomes of mild hypoxic-ischemic encephalopathy
(HIE) identified in the first 6 h of life are lacking. Objective To evaluate neurodevelopmental …

Early EEG grade and outcome at 5 years after mild neonatal hypoxic ischemic encephalopathy

DM Murray, CM O'Connor, CA Ryan… - …, 2016 - publications.aap.org
OBJECTIVE: More than half of all infants with neonatal hypoxic ischemic encephalopathy
(HIE) are graded as mild and do not meet current criteria for therapeutic hypothermia. These …

Safety and short-term outcomes of therapeutic hypothermia in preterm neonates 34-35 weeks gestational age with hypoxic-ischemic encephalopathy

R Rao, S Trivedi, Z Vesoulis, SM Liao, CD Smyser… - The Journal of …, 2017 - Elsevier
Objective To evaluate the safety and short-term outcomes of preterm neonates born at 34-35
weeks gestation with hypoxic-ischemic encephalopathy (HIE) treated with therapeutic …

Prospective research on infants with mild encephalopathy: the PRIME study

C Prempunpong, LF Chalak, J Garfinkle, B Shah… - Journal of …, 2018 - nature.com
Objective: To determine short-term outcomes of infants with evidence of hypoxia–ischemia
at birth and classified as mild neonatal encephalopathy (NE) at< 6 h of age. Study Design …

The frequency and severity of magnetic resonance imaging abnormalities in infants with mild neonatal encephalopathy

BH Walsh, J Neil, JA Morey, E Yang, MV Silvera… - The Journal of …, 2017 - Elsevier
Objective To assess and contrast the incidence and severity of abnormalities on cerebral
magnetic resonance imaging (MRI) between infants with mild, moderate, and severe …

Characteristics and short-term outcomes of neonates with mild hypoxic-ischemic encephalopathy treated with hypothermia

IR Goswami, H Whyte, P Wintermark… - Journal of …, 2020 - nature.com
Objective To compare the characteristics and outcomes of neonates with mild hypoxic-
ischemic encephalopathy (HIE) who received hypothermia versus standard care. Study …

Current practice of therapeutic hypothermia for mild hypoxic ischemic encephalopathy

CL Saw, A Rakshasbhuvankar, S Rao… - Journal of child …, 2019 - journals.sagepub.com
Context: Therapeutic hypothermia is the recommended treatment for neonates with
moderate or severe hypoxic ischemic encephalopathy (HIE). There is an increasing trend to …

Acute kidney injury in neonatal encephalopathy: an evaluation of the AWAKEN database

MJ Kirkley, L Boohaker, R Griffin, DE Soranno… - Pediatric …, 2019 - Springer
Background Acute kidney injury (AKI) is common in neonatal encephalopathy (NE) and is
associated with worse outcomes. Our objectives were to determine the incidence, risk …