[HTML][HTML] Nrf2 modulation in breast cancer

S Ghareghomi, M Habibi-Rezaei, M Arese, L Saso… - Biomedicines, 2022 - mdpi.com
Reactive oxygen species (ROS) are identified to control the expression and activity of
various essential signaling intermediates involved in cellular proliferation, apoptosis, and …

[HTML][HTML] Therapeutic potential of luteolin on cancer

M Çetinkaya, Y Baran - Vaccines, 2023 - mdpi.com
Cancer is a global concern, as the rate of incidence is increasing each year. The challenges
related to the current chemotherapy drugs, such as the concerns related to toxicity, turn to …

[HTML][HTML] Nutraceutical Role of Polyphenols and Triterpenes Present in the Extracts of Fruits and Leaves of Olea europaea as Antioxidants, Anti-Infectives and …

EE Rufino-Palomares, A Pérez-Jiménez… - Molecules, 2022 - mdpi.com
There is currently a worldwide consensus and recognition of the undoubted health benefits
of the so-called Mediterranean diet, with its intake being associated with a lower risk of …

[HTML][HTML] The anticancer mechanism of action of selected polyphenols in triple-negative breast cancer (TNBC)

R Farghadani, R Naidu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Breast cancer is a leadingcause of cancer-related deaths in women globally, with triple-
negative breast cancer (TNBC) being an aggressive subtype that lacks targeted therapies …

[HTML][HTML] Natural Nrf2 inhibitors: A review of their potential for cancer treatment

J Zhang, HX Xu, JQ Zhu, YX Dou… - International Journal of …, 2023 - ncbi.nlm.nih.gov
Nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that regulates redox
homeostasis, plays a pivotal role in several cellular processes such as cell proliferation and …

Luteolin, a flavone ingredient: Anticancer mechanisms, combined medication strategy, pharmacokinetics, clinical trials, and pharmaceutical researches

M Shi, Z Chen, H Gong, Z Peng, Q Sun… - Phytotherapy …, 2024 - Wiley Online Library
Current pharmaceutical research is energetically excavating the pharmacotherapeutic role
of herb‐derived ingredients in multiple malignancies' targeting. Luteolin is one of the major …

[HTML][HTML] The regulatory effect of phytochemicals on chronic diseases by targeting Nrf2-ARE signaling pathway

WJ He, CH Lv, Z Chen, M Shi, CX Zeng, DX Hou, S Qin - Antioxidants, 2023 - mdpi.com
Redox balance is essential to maintain the body's normal metabolism. Once disrupted, it
may lead to various chronic diseases, such as diabetes, neurodegenerative diseases …

[HTML][HTML] Luteolin attenuates the chemoresistance of osteosarcoma through inhibiting the PTN/β-catenin/MDR1 signaling axis by upregulating miR-384

T Qin, W Zhu, X Kan, L Li, D Wu - Journal of bone oncology, 2022 - Elsevier
Multidrug resistance (MDR) remains a critical bottleneck in successful treatment of
osteosarcoma (OS). Luteolin is a flavonoid compound that has been verified to increase the …

Extensive review on breast cancer its etiology, progression, prognostic markers, and treatment

H Swaminathan, K Saravanamurali, SA Yadav - Medical Oncology, 2023 - Springer
As the most frequent and vulnerable malignancy among women, breast cancer universally
manifests a formidable healthcare challenge. From a biological and molecular perspective, it …

[HTML][HTML] Nrf2-mediated therapeutic effects of dietary flavones in different diseases

W Huang, Y Zhong, B Gao, B Zheng… - Frontiers in Pharmacology, 2023 - frontiersin.org
Oxidative stress (OS) is a pathological status that occurs when the body's balance between
oxidants and antioxidant defense systems is broken, which can promote the development of …