Alkaloids as natural NRF2 inhibitors: Chemoprevention and cytotoxic action in Cancer

D Gjorgieva Ackova, V Maksimova, K Smilkov… - Pharmaceuticals, 2023 - mdpi.com
Being a controller of cytoprotective actions, inflammation, and mitochondrial function through
participating in the regulation of multiple genes in response to stress-inducing endogenous …

A scientometrics and visualization analysis of oxidative stress modulator Nrf2 in cancer profiles its characteristics and reveals its association with immune response

SB Guo, S Du, KY Cai, HJ Cai, WJ Huang, XP Tian - Heliyon, 2023 - cell.com
Background Nrf2, an essential and fascinating transcription factor, enjoys a dual property in
the occurrence and development of inflammation and cancer. For over two decades …

Nrf2-mediated therapeutic effects of dietary flavones in different diseases

W Huang, Y Zhong, B Gao, B Zheng… - Frontiers in Pharmacology, 2023 - frontiersin.org
Oxidative stress (OS) is a pathological status that occurs when the body's balance between
oxidants and antioxidant defense systems is broken, which can promote the development of …

[HTML][HTML] Luteolin attenuates the chemoresistance of osteosarcoma through inhibiting the PTN/β-catenin/MDR1 signaling axis by upregulating miR-384

T Qin, W Zhu, X Kan, L Li, D Wu - Journal of bone oncology, 2022 - Elsevier
Multidrug resistance (MDR) remains a critical bottleneck in successful treatment of
osteosarcoma (OS). Luteolin is a flavonoid compound that has been verified to increase the …

Application of luteolin in neoplasms and nonneoplastic diseases

K Rakoczy, J Kaczor, A Sołtyk, N Szymańska… - International Journal of …, 2023 - mdpi.com
Researchers are amazed at the multitude of biological effects of 3′, 4′, 5, 7-
tetrahydroxyflavone, more commonly known as luteolin, as it simultaneously has antioxidant …

Acetylcholine promotes chronic stress-induced lung adenocarcinoma progression via α5-nAChR/FHIT pathway

Y Jiao, G Kang, P Pan, H Fan, Q Li, X Li, J Li… - Cellular and Molecular …, 2023 - Springer
Chronic stress significantly elevates the expression levels of various neurotransmitters in the
tumour microenvironment, thereby promoting the cell growth and metastasis of lung …

[HTML][HTML] Energy metabolism pathways in breast cancer progression: The reprogramming, crosstalk, and potential therapeutic targets

X Zheng, H Ma, J Wang, M Huang, D Fu, L Qin… - Translational …, 2022 - Elsevier
Breast cancer (BC) is a malignant tumor that seriously endangers health in women. BC, like
other cancers, is accompanied by metabolic reprogramming. Among energy metabolism …

Synergistic combination of luteolin and asiatic acid on cervical cancer in vitro and in vivo

YH Chen, JX Wu, SF Yang, YH Hsiao - Cancers, 2023 - mdpi.com
Simple Summary This study was the first to demonstrate the anticancer effects of luteolin
(Lut) combined with asiatic acid (AsA) on CaSki and HeLa cervical cancer cells. Lut …

The risk of breast cancer between western and mediterranean dietary patterns

HH Tsai, JC Yu, HM Hsu, CH Chu, TM Chang, ZJ Hong… - Nutrients, 2023 - mdpi.com
Breast cancer is a significant public health problem globally and prevention strategies have
become of great interest as its incidence rises. Exploring the connection between dietary …

Cyperotundone combined with adriamycin induces apoptosis in MCF-7 and MCF-7/ADR cancer cells by ROS generation and NRF2/ARE signaling pathway

W Shao, X Wang, Z Liu, X Song, F Wang, X Liu… - Scientific Reports, 2023 - nature.com
Breast cancer has become the most prevalent cancer, globally. Adriamycin is a first-line
chemotherapeutic agent, however, cancer cells acquire resistance to it, which is one of the …