Mobocertinib (TAK-788): A Targeted Inhibitor of EGFR Exon 20 Insertion Mutants in Non–Small Cell Lung Cancer
F Gonzalvez, S Vincent, TE Baker, AE Gould, S Li… - Cancer Discovery, 2021 - AACR
Most EGFR exon 20 insertion (EGFR ex20ins) driver mutations in non–small cell lung
cancer (NSCLC) are insensitive to approved EGFR tyrosine kinase inhibitors (TKI). To …
cancer (NSCLC) are insensitive to approved EGFR tyrosine kinase inhibitors (TKI). To …
Distribution of KRASG12C Somatic Mutations across Race, Sex, and Cancer Type
KRAS G12C Somatic Mutations in Various Cancers A survey of more than 32,000 cancers in
the GENIE registry detected differences in the distribution of KRAS G12C mutations in …
the GENIE registry detected differences in the distribution of KRAS G12C mutations in …
Clinical and molecular characterization of early‐onset colorectal cancer
Background Colorectal cancer (CRC) incidence is increasing in adults younger than 50
years. This study evaluated clinical and molecular features to identify those features unique …
years. This study evaluated clinical and molecular features to identify those features unique …
Multiplex assessment of protein variant abundance by massively parallel sequencing
KA Matreyek, LM Starita, JJ Stephany, B Martin… - Nature …, 2018 - nature.com
Determining the pathogenicity of genetic variants is a critical challenge, and functional
assessment is often the only option. Experimentally characterizing millions of possible …
assessment is often the only option. Experimentally characterizing millions of possible …
The origins and genetic interactions of KRAS mutations are allele- and tissue-specific
Mutational activation of KRAS promotes the initiation and progression of cancers, especially
in the colorectum, pancreas, lung, and blood plasma, with varying prevalence of specific …
in the colorectum, pancreas, lung, and blood plasma, with varying prevalence of specific …
[HTML][HTML] Management of BRAF-mutant metastatic colorectal cancer: a review of treatment options and evidence-based guidelines
Background Colorectal cancer (CRC) is still a leading cause of cancer-related deaths in the
United States and worldwide, despite recent improvements in cancer management. CRC …
United States and worldwide, despite recent improvements in cancer management. CRC …
Clinical cancer genomic profiling
D Chakravarty, DB Solit - Nature Reviews Genetics, 2021 - nature.com
Technological innovation and rapid reduction in sequencing costs have enabled the
genomic profiling of hundreds of cancer-associated genes as a component of routine cancer …
genomic profiling of hundreds of cancer-associated genes as a component of routine cancer …
Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations
While tumor genome sequencing has become widely available in clinical and research
settings, the interpretation of tumor somatic variants remains an important bottleneck. Here …
settings, the interpretation of tumor somatic variants remains an important bottleneck. Here …
Identification of cancer driver genes based on nucleotide context
Cancer genomes contain large numbers of somatic mutations but few of these mutations
drive tumor development. Current approaches either identify driver genes on the basis of …
drive tumor development. Current approaches either identify driver genes on the basis of …
Quantitative evidence for early metastatic seeding in colorectal cancer
Both the timing and molecular determinants of metastasis are unknown, hindering treatment
and prevention efforts. Here we characterize the evolutionary dynamics of this lethal process …
and prevention efforts. Here we characterize the evolutionary dynamics of this lethal process …