Background Inflammation and oxidative damage caused by severe infections may be
attenuated by vitamin C. Methods We conducted a systematic review of randomized …

The vascular endothelium is crucial for the maintenance of vascular homeostasis. Moreover,
in sepsis, endothelial cells can acquire new properties and actively participate in the host's …

Background The combination therapy of hydrocortisone, vitamin C, and thiamine has been
proposed as a potential treatment in patients with sepsis and septic shock. However …

Sepsis is a potentially fatal condition characterized by organ dysfunction caused by an
imbalanced immune response to infection. Although an increased inflammatory response …

Background/Aim: Sepsis is a life-threatening biological condition that induces systemic
tissue and organ dysfunction and confers a high mortality risk. Although the use of …

Objective To investigate the clinical efficacy of vitamin C-containing therapy for patients with
sepsis. Methods PubMed, Embase, Cochrane Library, and ClinicalTrials. gov were searched …

Background: Sepsis and septic shock are associated with enormous mortality and health
care burden. Since the study of Marik et al suggested mortality benefit, there has been great …

Purpose To determine whether intravenous vitamin C compared with placebo, reduces
vasopressor requirements in patients with vasoplegic shock. Methods Double-blinded …

Background Vitamin C has potential protective effects through antioxidant and anti-
inflammatory properties. However, the effect of vitamin C supplementation on microvascular …

Objectives Vitamin C deficiency is common among patients with sepsis and has been
associated with poor clinical outcomes. Nevertheless, the effect of intravenous (IV) vitamin C …