The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …

Type 2 immunity is orchestrated by a canonical group of cytokines primarily produced by
innate lymphoid cells, group 2, and their adaptive counterparts, CD4+ helper type 2 cells …

The JAK/STAT signaling pathway plays a key role in cytokine signaling and is involved in
development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK/STAT …

The STAT3 story has almost 30 years of evolving history. First identified in 1994 as a pro-
inflammatory transcription factor, Signal Transducer and Activator of Transcription 3 (STAT3) …

Chronic mucocutaneous candidiasis (CMC) was recognized as a primary immunodeficiency
in the early 1970's. However, for almost 40 years, its genetic etiology remained unknown …

Type 2 inflammation is characterized by overexpression and heightened activity of type 2
cytokines, mediators and cells that drive neuroimmune activation and sensitization to …

The transcription factor STAT6 (Signal Transducer and Activator of Transcription 6) is a key
regulator of Th2 (T-helper 2) mediated allergic inflammation via the IL-4 (interleukin-4) JAK …

Inborn errors of immunity (IEIs) comprise a variety of immune conditions leading to
infections, autoimmunity, allergy, and cancer. Some IEIs have no identified mutation (s) …

Cytokines employ downstream Janus kinases (JAKs) to promote chronic inflammatory
diseases. JAK1-dependent type 2 cytokines drive allergic inflammation, and patients with …

Signal transducer and activator of transcription (STAT)-6 is a transcription factor central to
pro-allergic immune responses, although the function of human STAT6 at the whole …