Oral peptide delivery is trending again. Among the possible reasons are the recent
approvals of two oral peptide formulations, which represent a huge stride in the field. For the …

The limited therapeutic efficacy of oral medications against ulcerative colitis (UC) is
attributed to inadequate drug exposure to inflammation site in the colon. To address this …

In this work, simulations of intestinal peristalsis are performed to investigate the intraluminal
transport of macromolecules (MMs) and permeation enhancers (PEs). Properties of insulin …

In recent years, enzyme therapy strategies have rapidly evolved to catalyze essential
biochemical reactions with therapeutic potential. These approaches hold particular promise …

Therapeutic proteins have been employed for centuries and reached approximately 50% of
all drugs investigated. By 2023, they represented one of the top 10 largest-selling pharma …

Diabetes, characterized by hyperglycemia, is a major cause of death and disability
worldwide. Peptides, such as insulin and glucagon-like peptide-1 (GLP-1) analogs, have …

The crystallization of peptides offers a sustainable and inexpensive alternative to the
purification process. In this study, diglycine was crystallised in porous silica, showing the …

Hypoglycemic peptides have exhibited great clinical benefits for diabetics and body weight
control due to their high activity, high specificity, and low toxicity. However, frequent …

The oral delivery of protein and peptide drugs faces immense challenges due to the harsh
gastrointestinal (GI) environment, large molecular size, and low stability. Even though …

Orally administered peptides or proteins are garnering increasing preference owing to their
superiority in terms of patient compliance and convenience. However, the development of …