The current guideline represents the 6th edition of the “Japanese Clinical Practice Guideline
for Diabetes” which has been revised every three years since its first appearance in 2004 to …

Globally, approximately one in three of all adults suffer from multiple chronic conditions
(MCCs). This review provides a comprehensive overview of the resulting epidemiological …

Background Diabetes is one of the leading causes of death and disability worldwide, and
affects people regardless of country, age group, or sex. Using the most recent evidentiary …

Importance Prediabetes, an intermediate stage between normal glucose regulation and
diabetes, affects 1 in 3 adults in the US and approximately 720 million individuals …

Importance Overweight and obesity have been associated with adverse health effects.
Objective To systematically review evidence on benefits and harms of behavioral and …

Importance More than 35% of men and 40% of women in the United States are obese.
Obesity is associated with health problems such as increased risk for coronary heart …

Background Type 2 diabetes mellitus (T2DM) comprises the vast majority of all diabetes
cases in adults, with alarmingly increasing prevalence over the past few decades worldwide …

Objective To assess whether weight loss interventions for adults with obesity affect all cause,
cardiovascular, and cancer mortality, cardiovascular disease, cancer, and body weight …

Background Environmental and lifestyle changes, in addition to the ageing of populations,
are generally believed to account for the rapid global increase in type 2 diabetes prevalence …

In the past, different types of diet with a generally low-carbohydrate content (< 50–< 20
g/day) have been promoted, for weight loss and diabetes, and the effectiveness of a very low …