Heterotrimeric G protein-coupled receptors (GPCRs) comprise the largest receptor family in
mammals and are responsible for the regulation of most physiological functions. Besides …

Taste is the sensory system devoted primarily to a quality check of food to be ingested.
Although aided by smell and visual inspection, the final recognition and selection relies on …

Host-derived succinate accumulates in the airways during bacterial infection. Here, we show
that luminal succinate activates murine tracheal brush (tuft) cells through a signaling …

We used differential screening of cDNAs from individual taste receptor cells to identify
candidate taste transduction elements in mice. Among the differentially expressed clones …

The sense of taste plays a critical role in the life and nutritional status of humans and other
organisms. Human taste perception may be categorized according to four well known and …

Animals use their gustatory systems to evaluate the nutritious value, toxicity, sodium content,
and acidity of food. Although characterization of molecular identities that receive taste …

Among the products of enteroendocrine cells are the incretins glucagon-like peptide-1 (GLP-
1, secreted by L cells) and glucose-dependent insulinotropic peptide (GIP, secreted by K …

Taste buds are the transducing endorgans of gustation. Each taste bud comprises 50–100
elongated cells, which extend from the basal lamina to the surface of the tongue, where their …

When we edited in 2007 the first issue on transient receptor potential channel in the
Handbook of Experimental Pharmacology, we were all very excited by the progress in this …

An ever increasing number of reports about taste receptors in non-gustatory tissues suggest
that these molecules must have additional functions apart from taste. Of the extraoral tissues …