Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …

Sexual dimorphism refers to differences between biological sexes that extend beyond
sexual characteristics. In humans, sexual dimorphism in the immune response has been …

Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …

Osteoporosis is a metabolic disease characterized by decreased bone mineral density and
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …

Bone loss in postmenopausal osteoporosis is induced chiefly by an imbalance of bone-
forming osteoblasts and bone-resorbing osteoclasts. Salubrinal is a synthetic compound that …

Most studies aiming to identify epigenetic biomarkers do so from complex tissues that are
composed of many different cell-types. By definition, these cell-types vary substantially in …

Metabolic disorders are increasingly prevalent worldwide, leading to high rates of morbidity
and mortality. The variety of metabolic illnesses can be addressed through personalized …

Phenotypic variation in skeletal traits and diseases is the product of genetic and
environmental factors. Epigenetic mechanisms include information‐containing factors, other …

Skeletal aging begins after peak bone mass is reached; progressive bone loss then occurs.
Peak bone mass may occur at different ages in different skeletal sites and varies between …

Background DNA methylation is an epigenetic mark that is influenced by underlying genetic
profile, environment, and ageing. In addition to X-linked DNA methylation, sex-specific …