Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

Alzheimer's disease (AD) belongs to a group of neurodegenerative diseases collectively
designated as “tauopathies”, because they are characterized by the aggregation of …

The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar
disorder (BD), a severe mental illness arising from complex interactions between genes and …

Semaphorins, originally discovered as guidance cues for developing axons, are involved in
many processes that shape the nervous system during development, from neuronal …

Protein phosphatase 2A (PP2A) is a large family of enzymes that account for the majority of
brain Ser/Thr phosphatase activity. While PP2A enzymes collectively modulate most cellular …

Microtubule-associated protein tau is abnormally hyperphosphorylated and aggregated into
neurofibrillary tangles in brains of individuals with Alzheimer's disease (AD) and other …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by an
asymptomatic period of amyloid-β (Aβ) deposition as insoluble extracellular plaque …

Neurofibrillary tangles composed of hyperphosphorylated, aggregated tau are a common
pathological feature of tauopathies, including Alzheimer's disease. Abnormal …

It has been established for a long time that brain glucose metabolism is impaired in
Alzheimer's disease. Recent studies have demonstrated that impaired brain glucose …

Microtubule associated protein (MAP) tau is abnormally hyperphosphorylated in Alzheimer's
disease (AD) and related tauopathies; in this form it is the major protein subunit of paired …