Circulating tumor cells: a review of non–EpCAM-based approaches for cell enrichment and isolation

MT Gabriel, LR Calleja, A Chalopin, B Ory… - Clinical …, 2016 - academic.oup.com
BACKGROUND Circulating tumor cells (CTCs) are biomarkers for noninvasively measuring
the evolution of tumor genotypes during treatment and disease progression. Recent …

Updates on cytogenetics and molecular genetics of bone and soft tissue tumors:: Ewing sarcoma and peripheral primitive neuroectodermal tumors

AA Sandberg, JA Bridge - Cancer genetics and cytogenetics, 2000 - Elsevier
Cytogenetics of Bone and Soft Tissue Tumors [1]. In view of the remarkable developments in
this field since 1994, both in the cytogenetic and particularly in the molecular genetic …

Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases

WJ Allard, J Matera, MC Miller, M Repollet… - Clinical cancer …, 2004 - AACR
Purpose: The purpose of this study was to determine the accuracy, precision, and linearity of
the CellSearch system and evaluate the number of circulating tumor cells (CTCs) per 7.5 mL …

Antibody conjugated magnetic iron oxide nanoparticles for cancer cell separation in fresh whole blood

H Xu, ZP Aguilar, L Yang, M Kuang, H Duan, Y Xiong… - Biomaterials, 2011 - Elsevier
A highly efficient process using iron oxide magnetic nanoparticles (IO)-based
immunomagnetic separation of tumor cells from fresh whole blood has been developed. The …

ExoSD chips for high-purity immunomagnetic separation and high-sensitivity detection of gastric cancer cell-derived exosomes

Z Yu, S Lin, F Xia, Y Liu, D Zhang, F Wang… - Biosensors and …, 2021 - Elsevier
Gastric cancer cell-derived exosomes as biomarkers have a very high application potential
to the non-invasive detection of early-stage gastric cancer. However, the small size of …

Isolation of tumor cells using size and deformation

H Mohamed, M Murray, JN Turner… - Journal of Chromatography …, 2009 - Elsevier
The isolation and analysis of circulating tumor cells (CTCs) from blood are the subject of
intense research. Although tests to detect metastasis on a molecular level are available …

Cancer extracellular vesicles, tumoroid models, and tumor microenvironment

T Eguchi, M Sheta, M Fujii, SK Calderwood - Seminars in Cancer Biology, 2022 - Elsevier
Cancer extracellular vesicles (EVs), or exosomes, promote tumor progression through
enhancing tumor growth, initiating epithelial-to-mesenchymal transition, remodeling the …

Enrichment, detection and clinical significance of circulating tumor cells

SK Arya, B Lim, ARA Rahman - Lab on a Chip, 2013 - pubs.rsc.org
Circulating Tumor Cells (CTCs) are shed from primary or secondary tumors into blood
circulation. Accessing and analyzing these cells provides a non-invasive alternative to tissue …

Clinical significance of circulating tumor cells in blood from patients with gastrointestinal cancers

K Hiraiwa, H Takeuchi, H Hasegawa… - Annals of Surgical …, 2008 - Springer
Abstract Background Circulating tumor cells (CTCs) measured by the CellSearch system in
metastatic breast cancer have been reported to correlate with shorter overall survival. The …

Clinical significance of immunocytochemical detection of tumor cells using digital microscopy in peripheral blood and bone marrow of breast cancer patients

JY Pierga, C Bonneton, A Vincent-Salomon… - Clinical Cancer …, 2004 - AACR
Purpose: The presence of tumor cells in bone marrow has been reported to represent an
important prognostic indicator in breast cancer, but the clinical significance of circulating …