Improving human cancer therapy through the evaluation of pet dogs

AK LeBlanc, CN Mazcko - Nature Reviews Cancer, 2020 - nature.com
Comparative oncology clinical trials play an important and growing role in cancer research
and drug development efforts. These trials, typically conducted in companion (pet) dogs …

Evolutionary determinants of cancer

M Greaves - Cancer discovery, 2015 - AACR
Our understanding of cancer is being transformed by exploring clonal diversity, drug
resistance, and causation within an evolutionary framework. The therapeutic resilience of …

[HTML][HTML] The role of inflammation and inflammatory mediators in the development, progression, metastasis, and chemoresistance of epithelial ovarian cancer

SS Savant, S Sriramkumar, HM O'Hagan - Cancers, 2018 - mdpi.com
Inflammation plays a role in the initiation and development of many types of cancers,
including epithelial ovarian cancer (EOC) and high grade serous ovarian cancer (HGSC), a …

[HTML][HTML] Three-dimensional modelling of ovarian cancer: From cell lines to organoids for discovery and personalized medicine

C Yee, KA Dickson, MN Muntasir, Y Ma… - … in Bioengineering and …, 2022 - frontiersin.org
Ovarian cancer has the highest mortality of all of the gynecological malignancies. There are
several distinct histotypes of this malignancy characterized by specific molecular events and …

Deer antlers: the fastest growing tissue with least cancer occurrence

C Li, Y Li, W Wang, M Scimeca, G Melino… - Cell Death & …, 2023 - nature.com
Deer antlers are a bony organ solely able to acquired distinct unique attributes during
evolution and all these attributes are against thus far known natural rules. One of them is as …

Epithelial ovarian cancer experimental models

E Lengyel, JE Burdette, HA Kenny, D Matei, J Pilrose… - Oncogene, 2014 - nature.com
Epithelial ovarian cancer (OvCa) is associated with high mortality and, as the majority (>
75%) of women with OvCa have metastatic disease at the time of diagnosis, rates of survival …

[HTML][HTML] Preclinical models of epithelial ovarian cancer: practical considerations and challenges for a meaningful application

A Ciucci, M Buttarelli, A Fagotti, G Scambia… - Cellular and Molecular …, 2022 - Springer
Despite many improvements in ovarian cancer diagnosis and treatment, until now,
conventional chemotherapy and new biological drugs have not been shown to cure the …

Cisplatin–alginate conjugate liposomes for targeted delivery to EGFR-positive ovarian cancer cells

Y Wang, J Zhou, L Qiu, X Wang, L Chen, T Liu, W Di - Biomaterials, 2014 - Elsevier
Systemic side effects and low aqueous solubility have limited the clinical use of cisplatin
(CDDP) in ovarian carcinoma and have contributed to failures in developing effective drug …

The cheating cell: How evolution helps us understand and treat cancer

A Aktipis - 2020 - torrossa.com
This is a book about cancer: its ancient origins, its modern manifestations, and its future fate.
It is a book about where cancer came from, why it exists, and why it is so hard to cure. This is …

[HTML][HTML] Integrating environment and aging research: opportunities for synergy and acceleration

KMC Malecki, JK Andersen, AM Geller… - Frontiers in aging …, 2022 - frontiersin.org
Despite significant overlaps in mission, the fields of environmental health sciences and
aging biology are just beginning to intersect. It is increasingly clear that genetics alone does …