Improving human cancer therapy through the evaluation of pet dogs
AK LeBlanc, CN Mazcko - Nature Reviews Cancer, 2020 - nature.com
Comparative oncology clinical trials play an important and growing role in cancer research
and drug development efforts. These trials, typically conducted in companion (pet) dogs …
and drug development efforts. These trials, typically conducted in companion (pet) dogs …
Evolutionary determinants of cancer
M Greaves - Cancer discovery, 2015 - AACR
Our understanding of cancer is being transformed by exploring clonal diversity, drug
resistance, and causation within an evolutionary framework. The therapeutic resilience of …
resistance, and causation within an evolutionary framework. The therapeutic resilience of …
[HTML][HTML] The role of inflammation and inflammatory mediators in the development, progression, metastasis, and chemoresistance of epithelial ovarian cancer
SS Savant, S Sriramkumar, HM O'Hagan - Cancers, 2018 - mdpi.com
Inflammation plays a role in the initiation and development of many types of cancers,
including epithelial ovarian cancer (EOC) and high grade serous ovarian cancer (HGSC), a …
including epithelial ovarian cancer (EOC) and high grade serous ovarian cancer (HGSC), a …
[HTML][HTML] Three-dimensional modelling of ovarian cancer: From cell lines to organoids for discovery and personalized medicine
C Yee, KA Dickson, MN Muntasir, Y Ma… - … in Bioengineering and …, 2022 - frontiersin.org
Ovarian cancer has the highest mortality of all of the gynecological malignancies. There are
several distinct histotypes of this malignancy characterized by specific molecular events and …
several distinct histotypes of this malignancy characterized by specific molecular events and …
Deer antlers: the fastest growing tissue with least cancer occurrence
Deer antlers are a bony organ solely able to acquired distinct unique attributes during
evolution and all these attributes are against thus far known natural rules. One of them is as …
evolution and all these attributes are against thus far known natural rules. One of them is as …
Epithelial ovarian cancer experimental models
Epithelial ovarian cancer (OvCa) is associated with high mortality and, as the majority (>
75%) of women with OvCa have metastatic disease at the time of diagnosis, rates of survival …
75%) of women with OvCa have metastatic disease at the time of diagnosis, rates of survival …
[HTML][HTML] Preclinical models of epithelial ovarian cancer: practical considerations and challenges for a meaningful application
A Ciucci, M Buttarelli, A Fagotti, G Scambia… - Cellular and Molecular …, 2022 - Springer
Despite many improvements in ovarian cancer diagnosis and treatment, until now,
conventional chemotherapy and new biological drugs have not been shown to cure the …
conventional chemotherapy and new biological drugs have not been shown to cure the …
Cisplatin–alginate conjugate liposomes for targeted delivery to EGFR-positive ovarian cancer cells
Y Wang, J Zhou, L Qiu, X Wang, L Chen, T Liu, W Di - Biomaterials, 2014 - Elsevier
Systemic side effects and low aqueous solubility have limited the clinical use of cisplatin
(CDDP) in ovarian carcinoma and have contributed to failures in developing effective drug …
(CDDP) in ovarian carcinoma and have contributed to failures in developing effective drug …
The cheating cell: How evolution helps us understand and treat cancer
A Aktipis - 2020 - torrossa.com
This is a book about cancer: its ancient origins, its modern manifestations, and its future fate.
It is a book about where cancer came from, why it exists, and why it is so hard to cure. This is …
It is a book about where cancer came from, why it exists, and why it is so hard to cure. This is …
[HTML][HTML] Integrating environment and aging research: opportunities for synergy and acceleration
Despite significant overlaps in mission, the fields of environmental health sciences and
aging biology are just beginning to intersect. It is increasingly clear that genetics alone does …
aging biology are just beginning to intersect. It is increasingly clear that genetics alone does …