Obesity is a complex disease that affects whole body metabolism and is associated with an
increased risk of cardiovascular disease (CVD) and Type 2 diabetes (T2D). Physical …

For centuries, regular exercise has been acknowledged as a potent stimulus to promote,
maintain, and restore healthy functioning of nearly every physiological system of the human …

Emerging evidence indicates the beneficial effects of physical exercise on human health,
which depends on the intensity, training time, exercise type, environmental factors, and the …

Cardiovascular diseases are the most common cause of death in the world. One of the major
causes of cardiac death is excessive apoptosis. However, multiple pathways through …

Background: One of the negative effects of cardiac sympathetic hyperactivity is pathologic
hypertrophy. Recent studies have indicated that large tumor suppressor (LATS) is one of the …

Functional defects in mitochondrial biology causally contribute to various human diseases,
including cardiovascular disease. Impairment in oxidative phosphorylation, mitochondrial …

Cardiac remodeling is a physiological adaptation to aerobic exercise and which is
characterized by increases in ventricular volume and the number of cardiomyocytes. The …

Objective Hypertension (HTN) is among the leading causes of myocardial infarction, stroke,
and kidney disease. The MitoQ supplement is a mitochondrial-targeted antioxidant that …

Cardiac hypertrophy can cause heart failure. However, the mechanisms underlying the
progression of cardiac hypertrophy remain unclear. Emerging evidence suggests that …

MicroRNAs (miRNAs and miRs) are endogenous 19–22 nucleotide, small noncoding RNAs
with highly conservative and tissue specific expression. They can negatively modulate target …