Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect

Z Zhao, X Dai, C Li, X Wang, J Tian, Y Feng… - European journal of …, 2020 - Elsevier
The pyrazolone structural motif is a critical element of drugs aimed at different biological end-
points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates …

Overview of cannabidiol (CBD) and its analogues: Structures, biological activities, and neuroprotective mechanisms in epilepsy and Alzheimer's disease

H Li, Y Liu, D Tian, L Tian, X Ju, L Qi, Y Wang… - European journal of …, 2020 - Elsevier
Herein, 11 general types of natural cannabinoids from Cannabis sativa as well as 50 (-)-
CBD analogues with therapeutic potential were described. The underlying molecular …

An update of palmitoylethanolamide and luteolin effects in preclinical and clinical studies of neuroinflammatory events

M Cordaro, S Cuzzocrea, R Crupi - Antioxidants, 2020 - mdpi.com
The inflammation process represents of a dynamic series of phenomena that manifest
themselves with an intense vascular reaction. Neuroinflammation is a reply from the central …

[HTML][HTML] Bioinspired biomolecules: Mycosporine-like amino acids and scytonemin from Lyngbya sp. with UV-protection potentialities

S Fuentes-Tristan, R Parra-Saldivar, HMN Iqbal… - … of Photochemistry and …, 2019 - Elsevier
Since the beginning of life on Earth, cyanobacteria have been exposed to natural ultraviolet-
A radiation (UV-A, 315–400 nm) and ultraviolet-B radiation (UV-B, 280–315 nm), affecting …

A critical review of novel antibiotic resistance prevention approaches with a focus on postbiotics

MA Ozma, SR Moaddab, H Hosseini… - Critical reviews in …, 2023 - Taylor & Francis
Antibiotic resistance is a significant public health issue, causing illnesses that were once
easily treatable with antibiotics to develop into dangerous infections, leading to substantial …

Natural marine and terrestrial compounds as modulators of matrix metalloproteinases-2 (MMP-2) and MMP-9 in Alzheimer's disease

L Ciccone, J Vandooren, S Nencetti, E Orlandini - Pharmaceuticals, 2021 - mdpi.com
Several studies have reported neuroprotective effects by natural products. A wide range of
natural compounds have been investigated, and some of these may play a beneficial role in …

Molecular docking, tyrosinase, collagenase, and elastase inhibition activities of argan by-products

H Mechqoq, S Hourfane, M El Yaagoubi… - Cosmetics, 2022 - mdpi.com
The argan tree (Argania spinosa (L.) Skeels) is one of the most important floristic resources
in Morocco. This Moroccan endemic tree is known for its numerous therapeutic and …

Recent advances in biological properties of brown algae-derived compounds for nutraceutical applications

A Silva, L Cassani, C Grosso… - Critical Reviews in …, 2024 - Taylor & Francis
The increasing demand for nutraceuticals in the circular economy era has driven the
research toward studying bioactive compounds from renewable underexploited resources …

Polysaccharide extracted from Sarcandra glabra residue attenuate cognitive impairment by regulating gut microbiota in diabetic mice

M Ye, Y Liu, F Wang, X Yang, X Yang, X Gao… - International Journal of …, 2024 - Elsevier
Diabetic encephalopathy (DE), characterized by cognitive impairment, currently lacks
targeted treatment. Previous studies have shown that Sarcandra glabra extracted residue …

Metal chelation therapy and Parkinson's disease: A critical review on the thermodynamics of complex formation between relevant metal ions and promising or …

M Tosato, V Di Marco - Biomolecules, 2019 - mdpi.com
The present review reports a list of approximately 800 compounds which have been used,
tested or proposed for Parkinson's disease (PD) therapy in the year range 2014–2019 …