This article is the second of a series of 2 educational articles. In the first article, we described
the basic concepts of survival analysis, summarizing the common statistical methods and …

The burden of atherosclerotic cardiovascular disease (ASCVD) in high-income countries is
mostly borne by the elderly. With increasing life expectancy, clear guidance on sensible use …

Background Long-term outcomes after percutaneous coronary intervention (PCI) with
contemporary drug-eluting stents, as compared with coronary-artery bypass grafting …

Background Randomised controlled trials are considered the gold standard for testing the
efficacy of novel therapeutic interventions, and typically report the average treatment effect …

In December 2008, the US Food and Drug Administration issued guidance to the
pharmaceutical industry setting new expectations for the development of antidiabetes drugs …

Aims Stroke is often a devastating event among patients with heart failure with reduced
ejection (HFrEF). In COMMANDER HF, rivaroxaban 2.5 mg bid did not reduce the composite …

The learning healthcare system uses health information technology and the health data
infrastructure to apply scientific evidence at the point of clinical care while simultaneously …

Objectives The aim of this study was to investigate the incidence and impact on mortality of
repeat revascularization after index percutaneous coronary intervention (PCI) or coronary …

Advances in cardiovascular medicine fueled by innovative clinical trials have dramatically
improved the lives of patients worldwide. Commensurate with this progress has been a …

Consensus as to best practices for the selection, reporting, and interpretation of primary and
secondary outcomes of randomized controlled trials is lacking. We reviewed the strategies …