Targeting the NLRP3 inflammasome in cardiovascular diseases
The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …
The NLRP3 inflammasome: Mechanism of action, role in disease and therapies
L Wang, AV Hauenstein - Molecular aspects of medicine, 2020 - Elsevier
NLRP3 is the best characterized cytosolic nod-like pattern recognition receptor which can
detect microbial motifs, endogenous danger and stress signals. Activation of NLRP3 leads to …
detect microbial motifs, endogenous danger and stress signals. Activation of NLRP3 leads to …
Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome
The NLRP3 inflammasome can be activated by stimuli that include nigericin, uric acid
crystals, amyloid-β fibrils and extracellular ATP. The mitotic kinase NEK7 licenses the …
crystals, amyloid-β fibrils and extracellular ATP. The mitotic kinase NEK7 licenses the …
NOD-like receptors and inflammasomes: A review of their canonical and non-canonical signaling pathways
JM Platnich, DA Muruve - Archives of biochemistry and biophysics, 2019 - Elsevier
The NOD-like receptor (NLR) family of proteins is a group of pattern recognition receptors
(PRRs) known to mediate the initial innate immune response to cellular injury and stress …
(PRRs) known to mediate the initial innate immune response to cellular injury and stress …
Enzymatic noncovalent synthesis
Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …
[HTML][HTML] Pyroptosis and its role in autoimmune disease: a potential therapeutic target
R You, X He, Z Zeng, Y Zhan, Y Xiao… - Frontiers in …, 2022 - frontiersin.org
Autoimmune diseases are a group of heterogeneous diseases with diverse clinical
manifestations that can be divided into systemic and organ-specific. The common etiology of …
manifestations that can be divided into systemic and organ-specific. The common etiology of …
[HTML][HTML] Role of pyroptosis in spinal cord injury and its therapeutic implications
A Al Mamun, Y Wu, I Monalisa, C Jia, K Zhou… - Journal of advanced …, 2021 - Elsevier
Background Currently, spinal cord injury (SCI) is a pathological incident that triggers several
neuropathological conditions, leading to the initiation of neuronal damage with several pro …
neuropathological conditions, leading to the initiation of neuronal damage with several pro …
[HTML][HTML] STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection
W Wang, D Hu, C Wu, Y Feng, A Li, W Liu… - PLoS …, 2020 - journals.plos.org
One of the fundamental reactions of the innate immune responses to pathogen infection is
the release of pro-inflammatory cytokines, including IL-1β, processed by the NLRP3 …
the release of pro-inflammatory cytokines, including IL-1β, processed by the NLRP3 …
[HTML][HTML] The advanced glycation end-products (AGEs)/ROS/NLRP3 inflammasome axis contributes to delayed diabetic corneal wound healing and nerve regeneration
L Wan, X Bai, Q Zhou, C Chen, H Wang… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Diabetic keratopathy (DK) is an important diabetic complication at the ocular surface.
Chronic low-grade inflammation mediated by the NLRP3 inflammasome promotes …
Chronic low-grade inflammation mediated by the NLRP3 inflammasome promotes …
Ibrutinib alleviates LPS-induced neuroinflammation and synaptic defects in a mouse model of depression
Previous studies have demonstrated a close association between an altered immune
system and major depressive disorders, and inhibition of neuroinflammation may represent …
system and major depressive disorders, and inhibition of neuroinflammation may represent …