There are over 80 million people currently living who have had a stroke. The ischemic injury
in the brain starts a cascade of events that lead to neuronal death, inducing …

Dysregulated inflammasome activation and interleukin (IL)-1β production are associated
with several inflammatory disorders. Three different routes can lead to inflammasome …

The COVID-19 pandemic, caused by SARS-CoV-2 infection, remains a dramatic threat to
human life and economic well-being worldwide. Significant heterogeneity in the severity of …

This review takes a closer look at the structural components of the molecules involved in the
processes leading to caspase-1 activation. Interleukins 1β and 18 (IL-1β, IL-18) are well …

Accumulating evidence indicates a pivotal role for chronic inflammatory processes in the
pathogenesis of neurodegenerative and psychiatric disorders. G protein-coupled formyl …

Inflammation is a hallmark in many forms of cancer; with colitis-associated colorectal cancer
(CAC) being a progressive intestinal inflammation due to inflammatory bowel disease (IBD) …

Diabetic nephropathy (DN) is one of the most common complications of diabetes and the
main cause of end-stage renal disease (ESRD). The inflammatory response plays a key role …

Aims Montelukast, a cysteinyl leukotriene receptor (CysLTR) 1 antagonist, is emerging as an
attractive strategy to curtail diabetic complications; however, its role in aortic and testicular …

Background. Grave's disease (GD) and Hashimoto's thyroiditis (HT) are autoimmune
diseases of the thyroid gland in which genetic predisposition plays a major role in their …

We previously reported that tumor inflammasomes play a key role in tumor control and act as
favorable prognostic markers in nasopharyngeal carcinoma (NPC). Activated …