Initial treatment choices to achieve sustained response in major depression: a systematic review and network meta‐analysis
TA Furukawa, K Shinohara, E Sahker… - World …, 2021 - Wiley Online Library
Major depression is often a relapsing disorder. It is therefore important to start its treatment
with therapies that maximize the chance of not only getting the patients well but also keeping …
with therapies that maximize the chance of not only getting the patients well but also keeping …
Discontinuation of antidepressants after remission with antidepressant medication in major depressive disorder: a systematic review and meta-analysis
A significant clinical issue encountered after a successful acute major depressive disorder
(MDD) treatment is the relapse of depressive symptoms. Although continuing maintenance …
(MDD) treatment is the relapse of depressive symptoms. Although continuing maintenance …
Vitamin D supplementation ameliorates severity of major depressive disorder
Major depressive disorder is a serious neuropsychiatric disease that leads to significant
impairment in social functioning and increased morbidity and mortality. Low vitamin D (25 …
impairment in social functioning and increased morbidity and mortality. Low vitamin D (25 …
Resting state functional connectivity patterns as biomarkers of treatment response to escitalopram in patients with major depressive disorder
Rational With no available response biomarkers, matching an appropriate antidepressant to
an individual can be a lengthy process. Improving understanding of processes underlying …
an individual can be a lengthy process. Improving understanding of processes underlying …
Fast-acting antidepressant-like effects of Reelin evaluated in the repeated-corticosterone chronic stress paradigm
The present report examines the effects of repeated or single intrahippocampal Reelin
infusions on measures of depressive-like behavior, cognition, and hippocampal …
infusions on measures of depressive-like behavior, cognition, and hippocampal …
Effect of adverse childhood experiences on hypothalamic–pituitary–adrenal (HPA) axis function and antidepressant efficacy in untreated first episode patients with …
JZ Yang, CY Kang, J Yuan, Y Zhang, YJ Wei… - …, 2021 - Elsevier
Adverse childhood experiences (ACEs) has been associated not only with an increased
vulnerability for stress-related psychiatric disorders but also with distinct alterations of the …
vulnerability for stress-related psychiatric disorders but also with distinct alterations of the …
Pain pathways and potential new targets for pain relief
M Wang, B Thyagarajan - Biotechnology and applied …, 2022 - Wiley Online Library
Pain is an unpleasant sensory and emotional experience that affects a sizable percentage of
people on a daily basis. Sensory neurons known as nociceptors built specifically to detect …
people on a daily basis. Sensory neurons known as nociceptors built specifically to detect …
The Contribution of Genetic Testing in Optimizing Therapy for Patients with Recurrent Depressive Disorder
RI Platona, F Voiță-Mekeres, C Tudoran… - Clinics and …, 2024 - mdpi.com
(1) Background: The aim of this study was to analyze the impact of pharmacogenetic-guided
antidepressant therapy on the 12-month evolution of the intensity of depressive symptoms in …
antidepressant therapy on the 12-month evolution of the intensity of depressive symptoms in …
Ketamine rescues hippocampal reelin expression and synaptic markers in the repeated-corticosterone chronic stress paradigm
JN Johnston, JS Thacker, C Desjardins… - Frontiers in …, 2020 - frontiersin.org
Depression is the leading cause of disability worldwide, which necessitates novel
therapeutics and biomarkers to approach treatment of this neuropsychiatric disorder. To …
therapeutics and biomarkers to approach treatment of this neuropsychiatric disorder. To …
The preclinical discovery and development of agomelatine for the treatment of depression
G Konstantakopoulos, S Dimitrakopoulos… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Under the treatment of commonly used antidepressants, many patients with
major depressive disorder (MDD) do not achieve remission. All previous first-line treatments …
major depressive disorder (MDD) do not achieve remission. All previous first-line treatments …