Septic cardiomyopathy: from basics to management choices

N Ravikumar, MA Sayed, CJ Poonsuph… - Current problems in …, 2021 - Elsevier
Septic cardiomyopathy (SCM) is increasingly recognized as a potential complication of
septic shock; it is understood to be a reversible left ventricular systolic dysfunction. The …

Mining helminths for novel therapeutics

KE Lothstein, WC Gause - Trends in molecular medicine, 2021 - cell.com
Helminths are an emerging source of therapeutics for dysregulated inflammatory diseases.
Excretory/secretory (ES) molecules, released during infection, are responsible for many of …

IL-6/STAT3 signaling promotes cardiac dysfunction by upregulating FUNDC1-dependent mitochondria-associated endoplasmic reticulum membranes formation in …

T Jiang, D Peng, W Shi, J Guo, S Huo, L Men… - Frontiers in …, 2022 - frontiersin.org
Aims Cytokine storm is closely related to the initiation and progression of sepsis, and the
level of IL-6 is positively correlated with mortality and organ dysfunction. Sepsis-induced …

Therapeutic Efficacy of Excretory-Secretory Products of Trichinella spiralis Adult Worms on Sepsis-Induced Acute Lung Injury in a Mouse Model

H Li, D Qiu, H Yang, Y Yuan, L Wu, L Chu… - Frontiers in Cellular …, 2021 - frontiersin.org
Acute lung injury (ALI) is a common complication of systemic inflammation or sepsis with
high morbidity and mortality. Although many studies have confirmed that helminth-derived …

Therapeutic Effect of Schistosoma japonicum Cystatin on Atherosclerotic Renal Damage

H Yang, H Li, W Chen, Z Mei, Y Yuan… - Frontiers in cell and …, 2021 - frontiersin.org
Atherosclerosis is a chronic inflammation of the arterial vessel wall driven by lipid
metabolism disorders. Although helminthic infection and their derivatives have been …

Schistosoma japonicum Cystatin Alleviates Sepsis Through Activating Regulatory Macrophages

H Xie, L Wu, X Chen, S Gao, H Li, Y Yuan… - Frontiers in Cellular …, 2021 - frontiersin.org
Multi-organ failure caused by the inflammatory cytokine storm induced by severe infection is
the major cause of death for sepsis. Sj-Cys is a cysteine protease inhibitor secreted by …

Schistosome infection and schistosome-derived products as modulators for the prevention and alleviation of immunological disorders

Y Mu, DP McManus, N Hou, P Cai - Frontiers in Immunology, 2021 - frontiersin.org
Parasitic helminths, comprising the flatworms (tapeworms and flukes) and nematodes
(roundworms), have plagued humans persistently over a considerable period of time. It is …

The Fight Against Severe COVID-19: Can Parasitic Worms Contribute?

P Cai, Y Mu, DP McManus - Frontiers in Immunology, 2022 - frontiersin.org
As of 31 December 2021, COVID-19, caused by infection with SARS-CoV-2, had been
confirmed in more than 285 million people worldwide, with more than 5.4 million dead …

Exogenous fetuin‐A protects against sepsis‐induced myocardial injury by inhibiting oxidative stress and inflammation in mice

V Sidheeque Hassan, M Hanifa… - Fundamental & …, 2023 - Wiley Online Library
Sepsis‐induced myocardial injury is a consequence of septicemia and is one of the major
causes of death in intensive care units. A serum glycoprotein called fetuin‐A is secreted …

Selenium supplementation protects against lipopolysaccharide-induced heart injury via sting pathway in mice

X Wang, B Yang, HL Cao, RY Wang, ZY Lu… - … Trace Element Research, 2021 - Springer
Sepsis-induced myocardial dysfunctions are associated with high morbidity and mortality.
Selenium, an essential trace element, has been reported to exert anti-inflammation, anti …