Neural control of the female urethral and anal rhabdosphincters and pelvic floor muscles

KB Thor, WC de Groat - American Journal of Physiology …, 2010 - journals.physiology.org
The urethral rhabdosphincter and pelvic floor muscles are important in maintenance of
urinary continence and in preventing descent of pelvic organs [ie, pelvic organ prolapse …

Assessing neurogenic lower urinary tract dysfunction after spinal cord injury: Animal models in preclinical neuro-urology research

AW Doelman, F Streijger, SJA Majerus, MS Damaser… - Biomedicines, 2023 - mdpi.com
Neurogenic bladder dysfunction is a condition that affects both bladder storage and voiding
function and remains one of the leading causes of morbidity after spinal cord injury (SCI) …

Nerve regeneration restores supraspinal control of bladder function after complete spinal cord injury

YS Lee, CY Lin, HH Jiang, M DePaul… - Journal of …, 2013 - Soc Neuroscience
A life-threatening disability after complete spinal cord injury is urinary dysfunction, which is
attributable to lack of regeneration of supraspinal pathways that control the bladder …

Transplantation of neural progenitor cells in chronic spinal cord injury

Y Jin, J Bouyer, JS Shumsky, C Haas, I Fischer - Neuroscience, 2016 - Elsevier
Previous studies demonstrated that neural progenitor cells (NPCs) transplanted into a
subacute contusion injury improve motor, sensory, and bladder function. In this study we …

FTY720 reduces inflammation and promotes functional recovery after spinal cord injury

KD Lee, WN Chow, C Sato-Bigbee, MR Graf… - Journal of …, 2009 - liebertpub.com
A robust and complex inflammatory cascade is known to be a prominent component of
secondary injury following spinal cord injury (SCI). Specifically, the concept of trauma …

A novel urodynamic model for lower urinary tract assessment in awake rats

MP Schneider, FM Hughes Jr, AK Engmann… - BJU …, 2015 - Wiley Online Library
Objectives To develop a urodynamic model incorporating external urethral sphincter (EUS)
electromyography (EMG) in awake rats. Materials and Methods Bladder catheters and EUS …

Enhanced susceptibility to urinary tract infection in the spinal cord-injured host with neurogenic bladder

ZR Balsara, SS Ross, PC Dolber, JS Wiener… - Infection and …, 2013 - Am Soc Microbiol
Neurogenic bladder predisposes to recurrent urinary tract infections (UTI) and renal failure,
and susceptibility is commonly ascribed to urinary stasis from elevated residual urine …

Transplantation and repair: combined cell implantation and chondroitinase delivery prevents deterioration of bladder function in rats with complete spinal cord injury

K Fouad, DD Pearse, W Tetzlaff, R Vavrek - Spinal Cord, 2009 - nature.com
Study design: Additional examination. In this study, we report changes in bladder function
after a combined treatment that was designed to study axonal regeneration after complete …

A bilateral cervical contusion injury model in mice: assessment of gripping strength as a measure of forelimb motor function

RM Aguilar, O Steward - Experimental neurology, 2010 - Elsevier
Here, we describe a bilateral cervical contusion model for mice. Adult female mice received
graded bilateral contusion injuries at cervical level 5 (C5) using a commercially available …

Thoracolumbar epidural stimulation effects on bladder and bowel function in uninjured and chronic transected anesthetized rats

RF Hoey, D Medina-Aguiñaga, F Khalifa… - Scientific reports, 2022 - nature.com
Pre-clinical studies have shown that spinal cord epidural stimulation (scES) at the level of
pelvic and pudendal nerve inputs/outputs (L5-S1) alters storage and/or emptying functions …