FAP-targeted PET imaging in gastrointestinal malignancies: a comprehensive review

A Arçay Öztürk, P Flamen - Cancer Imaging, 2023 - Springer
F18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG
PET/CT) plays a crucial role in tumour diagnosis, staging, and therapy response evaluation …

Fibroblast activation protein inhibitor tracers and their preclinical, translational, and clinical status in China

L Zhao, F Kang, Y Pang, J Fang, L Sun… - Journal of Nuclear …, 2024 - Soc Nuclear Med
Quinoline-based fibroblast activation protein (FAP) inhibitors (FAPIs) have recently emerged
as a focal point in global nuclear medicine, underscored by their promising applications in …

[18F] AlF-NOTA-FAPI-04 PET/CT can predict treatment response and survival in patients receiving chemotherapy for inoperable pancreatic ductal adenocarcinoma

Z Zhu, K Cheng, Z Yun, X Zhang, X Hu, J Liu… - European Journal of …, 2023 - Springer
Purpose We investigated whether uptake of [18F] AlF-NOTA-FAPI-04 on positron emission
tomography/computed tomography (PET/CT) could predict treatment response and survival …

From basic research to clinical application: targeting fibroblast activation protein for cancer diagnosis and treatment

Z Zhang, J Tao, J Qiu, Z Cao, H Huang, J Xiao… - Cellular Oncology, 2024 - Springer
Purpose This study aims to review the multifaceted roles of a membrane protein named
Fibroblast Activation Protein (FAP) expressed in tumor tissue, including its molecular …

PET/CT FAPI: Procedure and evidence review in oncology: Autores

AP Caresia, JJ Rosales, MR Fraile, AA Öztürk… - Revista Española de …, 2024 - Elsevier
Neoplasms are composed of malignant tumor cells, which are surrounded by other non-
tumor cellular elements, in what has been defined as the microenvironment or tumor stroma …

Clinical applications of fibroblast activation protein‐targeted theranostics in oncologic and nononcologic disease: Current status and future directions

H Fu, W Guo, J Huang, H Wu, H Chen - iRADIOLOGY, 2023 - Wiley Online Library
Quinoline‐based fibroblast activation protein (FAP) inhibitor (FAPI)‐based positron emission
tomography (PET) imaging and radioligand therapy (RLT) are being investigated for use in a …

18F-FAPI-04 PET/CT parameters predict PD-L1 expression in esophageal squamous cell carcinoma

Y Zhao, J Ren - Frontiers in Immunology, 2023 - frontiersin.org
Purpose This prospective study examined whether metabolism parameters obtained using
the tracer 18F-AlFNOTA-fibroblast activation protein inhibitor (FAPI)-04 (denoted as 18F …

PET/TC con FAPI: procedimiento y revisión de la evidencia en oncología

APC Aróztegui, JJ Rosales, MR Fraile… - Revista Española de …, 2024 - Elsevier
Las neoplasias se componen de células malignas tumorales que se encuentran rodeadas
de diversos elementos celulares no tumorales, que conforman el microambiente o estroma …

Visualization of metabolic parameters after colorectal carcinoma patients using [68Ga] Ga-FAPI PET

R Sun, G Zeng, Z Huang, X Chen - 2023 - researchsquare.com
Background This study evaluated the relationship between metabolic parameters derived
from gallium 68-labeled fibroblast-activation protein inhibitor ([68 Ga] Ga-FAPI) and Tumor …

Integrated 68Ga-FAPI-04 PET/MR in Pancreatic Cancer: Prediction of Tumor Response and Tumor Resectability After Neoadjuvant Therapy

Z Zhang, S Guo, C Cheng, K Cao, H Jiang… - Clinical Nuclear …, 2022 - journals.lww.com
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