Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy

AM Thomas, M Fidelle, B Routy, G Kroemer… - Nature reviews Clinical …, 2023 - nature.com
Oncogenesis is associated with intestinal dysbiosis, and stool shotgun metagenomic
sequencing in individuals with this condition might constitute a non-invasive approach for …

Bodywide ecological interventions on cancer

G Kroemer, JL McQuade, M Merad, F André… - Nature medicine, 2023 - nature.com
Historically, cancer research and therapy have focused on malignant cells and their tumor
microenvironment. However, the vascular, lymphatic and nervous systems establish long …

[HTML][HTML] Longitudinal gut microbiome changes in immune checkpoint blockade-treated advanced melanoma

JR Björk, LA Bolte, A Maltez Thomas, KA Lee… - Nature Medicine, 2024 - nature.com
Multiple clinical trials targeting the gut microbiome are being conducted to optimize
treatment outcomes for immune checkpoint blockade (ICB). To improve the success of these …

[HTML][HTML] Physical activity as the best supportive care in cancer: the clinician's and the researcher's perspectives

C Torregrosa, F Chorin, EEM Beltran, C Neuzillet… - Cancers, 2022 - mdpi.com
Simple Summary This literature review on adapted physical exercise has been written in
order to raise awareness of medical staff to this central theme in the management of cancer …

[HTML][HTML] Recent advances in cellular signaling interplay between redox metabolism and autophagy modulation in cancer: an overview of molecular mechanisms and …

MA Rahman, KR Ahmed, F Haque, MN Park, B Kim - Antioxidants, 2023 - mdpi.com
Autophagy is a fundamental homeostatic process in which certain cellular components are
ingested by double-membrane autophagosomes and then degraded to create energy or to …

[HTML][HTML] The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment

A Ungvari, R Gulej, B Csik, P Mukli, S Negri, S Tarantini… - Nutrients, 2023 - mdpi.com
As aging societies in the western world face a growing prevalence of vascular cognitive
impairment and Alzheimer's disease (AD), understanding their underlying causes and …

[HTML][HTML] Natural-product-based, carrier-free, noncovalent nanoparticles for tumor chemo-photodynamic combination therapy

Z Wang, L Yang - Pharmacological Research, 2024 - Elsevier
Cancer, with its diversity, heterogeneity, and complexity, is a significant contributor to global
morbidity, disability, and mortality, highlighting the necessity for transformative treatment …

[HTML][HTML] Shedding Light on the Hidden Benefit of Porphyridium cruentum Culture

D Liberti, P Imbimbo, E Giustino, L D'Elia, M Silva… - Antioxidants, 2023 - mdpi.com
Microalgae can represent a reliable source of natural compounds with different activities.
Here, we evaluated the antioxidant and anti-inflammatory activity of sulfated …

Dietary fibers affecting gastrointestinal immunity

L Zitvogel, G Kroemer - Trends in Immunology, 2023 - cell.com
Dietary fibers, including chitin, have a major impact on gastrointestinal (GI) physiology and
immunity. Two recent articles, by Parrish et al. and Kim et al., credit depletion of dietary fibers …

[HTML][HTML] Aging and cancer

L Montégut, C López-Otín, G Kroemer - Molecular Cancer, 2024 - Springer
Aging and cancer exhibit apparent links that we will examine in this review. The null
hypothesis that aging and cancer coincide because both are driven by time, irrespective of …