DNA origami has emerged as a powerful method to generate DNA nanostructures with
dynamic properties and nanoscale control. These nanostructures enable complex …

Recent developments in synthetic biology may bring the bottom-up generation of a synthetic
cell within reach. A key feature of a living synthetic cell is a functional cell cycle, in which …

Cytoskeletal elements, like actin and myosin, have been reconstituted inside lipid vesicles
toward the vision to reconstruct cells from the bottom up. Here, we realize the de novo …

Bottom-up and top-down approaches to synthetic biology each employ distinct
methodologies with the common aim to harness living systems. Here, we realize a strategic …

The interplay between nucleic acids and lipids underpins several key processes in
molecular biology, synthetic biotechnology, vaccine technology, and nanomedicine. These …

Membrane morphology and its dynamic adaptation regulate many cellular functions, which
are often mediated by membrane proteins. Advances in DNA nanotechnology have enabled …

DNA origami enables the bottom-up construction of chemically addressable, nanoscale
objects with user-defined shapes and tailored functionalities. As such, not only can DNA …

DNA nanotechnology is a unique field, where physics, chemistry, biology, mathematics,
engineering, and materials science can elegantly converge. Since the original proposal of …

The development and bottom-up assembly of synthetic cells with a functional cytoskeleton
sets a major milestone to understand cell mechanics and to develop man-made machines …

Cells can precisely program the shape and lateral organization of their membranes using
protein machinery. Aiming to replicate a comparable degree of control, here we introduce …