Caspases are proteases of clan CD and were described for the first time more than two
decades ago. They play critical roles in the control of regulated cell death pathways …

The role of caspase proteases in regulated processes such as apoptosis and inflammation
has been studied for more than two decades, and the activation cascades are known in …

Caspases are a family of proteases found in all metazoans, including a dozen in humans,
that drive the terminal stages of apoptosis as well as other cellular remodeling and …

We previously demonstrated that tumour necrosis factor (TNF)‐induced ceramide production
by endosomal acid sphingomyelinase (A‐SMase) couples to apoptosis signalling via …

Background: The cancer is still a major cause of death worldwide. Among different targets to
design anticancer agents, caspase-3 is an important target as its cleavage and activation …

Despite the emergence of advanced therapeutics such as targeted therapy and
immunotherapy in the modern oncology, cytotoxic chemotherapy still remains as the first-line …

The ability to routinely engineer protease specificity can allow us to better understand and
modulate their biology for expanded therapeutic and industrial applications. Here, we report …

Caspase-3 and-7 are considered functionally redundant proteases with similar proteolytic
specificities. We performed a proteome-wide screen on a mouse macrophage lysate using …

Caspase-6 is an apoptotic cysteine protease that also governs disease progression in
Huntington's and Alzheimer's diseases. Caspase-6 is of great interest as a target for …

Caspase-3 is an attractive therapeutic target for treatment of diseases involving disregulated
apoptosis. We report here the mechanism of caspase-3 inactivation by isoquinoline-1, 3, 4 …