Mangiferin: a natural miracle bioactive compound against lifestyle related disorders

M Imran, MS Arshad, MS Butt, JH Kwon… - Lipids in health and …, 2017 - Springer
The current review article is an attempt to explain the therapeutic potential of mangiferin, a
bioactive compound of the mango, against lifestyle-related disorders. Mangiferin (2-β-D …

Therapeutic potential of mangiferin in the treatment of various neuropsychiatric and neurodegenerative disorders

V Walia, SK Chaudhary, NK Sethiya - Neurochemistry international, 2021 - Elsevier
Xanthones are important chemical class of bioactive products that confers therapeutic
benefits. Of several xanthones, mangiferin is known to be distributed widely across several …

Enhancing biopharmaceutical attributes of phospholipid complex-loaded nanostructured lipidic carriers of mangiferin: systematic development, characterization and …

RK Khurana, AK Bansal, S Beg, AJ Burrow… - International journal of …, 2017 - Elsevier
Mangiferin (Mgf), largely expressed out from the leaves and stem bark of Mango, is a potent
antioxidant. However, its in vivo activity gets tremendously reduced owing to poor aqueous …

Pharmacological properties of mangiferin: Bioavailability, mechanisms of action and clinical perspectives

J Zivković, KA Kumar, R Rushendran, K Ilango… - Naunyn-Schmiedeberg's …, 2024 - Springer
This review aims to provide an in-depth analysis of the pharmacological properties of
mangiferin, focusing primarily on its bioavailability and mechanisms of action, and its …

Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for …

L Lindemann, RH Porter, SH Scharf… - … of Pharmacology and …, 2015 - ASPET
Major depressive disorder (MDD) is a serious public health burden and a leading cause of
disability. Its pharmacotherapy is currently limited to modulators of monoamine …

Dual Piperidine-Based Histamine H3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain

K Szczepańska, T Karcz, M Dichiara… - Journal of Medicinal …, 2023 - ACS Publications
In search of new dual-acting histamine H3/sigma-1 receptor ligands, we designed a series
of compounds structurally based on highly active in vivo ligands previously studied and …

Animal models of gastrointestinal and liver diseases. Animal models of visceral pain: pathophysiology, translational relevance, and challenges

B Greenwood-Van Meerveld… - American Journal …, 2015 - journals.physiology.org
Visceral pain describes pain emanating from the thoracic, pelvic, or abdominal organs. In
contrast to somatic pain, visceral pain is generally vague, poorly localized, and …

[HTML][HTML] Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice

K Sałat, B Filipek - Journal of Zhejiang University. Science. B, 2015 - ncbi.nlm.nih.gov
The aim of this research was to assess the antinociceptive activity of the transient receptor
potential (TRP) channel TRPV1, TRPM8, and TRPA1 antagonists in neurogenic, tonic, and …

The multifaceted role of mangiferin in health and diseases: A review

A Jangra, MK Arora, A Kisku, S Sharma - Advances in Traditional …, 2021 - Springer
A wide range of natural products including, flavonoids have been studied for their
therapeutic potential in different diseases. Mangiferin (2-cbd-glucopyranosyl 1, 3, 6, 7 …

Mangiferin, a natural glucoxilxanthone, inhibits mitochondrial dynamin-related protein 1 and relieves aberrant mitophagic proteins in mice model of Parkinson's …

XL Wang, ST Feng, YT Wang, NN Zhang, ZY Guo… - Phytomedicine, 2022 - Elsevier
Background Parkinson's disease (PD) is the second most common neurodegenerative
disease featured to mitochondrial dysfunction in neuronal cells. Dynamin-related protein 1 …