Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance
RCR Meex, MJ Watt - Nature Reviews Endocrinology, 2017 - nature.com
Hepatic steatosis is an underlying feature of nonalcoholic fatty liver disease (NAFLD), which
is the most common form of liver disease and is present in up to∼ 70% of individuals who …
is the most common form of liver disease and is present in up to∼ 70% of individuals who …
Recommendations for good practice in MS-based lipidomics
In the last 2 decades, lipidomics has become one of the fastest expanding scientific
disciplines in biomedical research. With an increasing number of new research groups to …
disciplines in biomedical research. With an increasing number of new research groups to …
Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is common and partially heritable and has no
effective treatments. We carried out a genome-wide association study (GWAS) meta …
effective treatments. We carried out a genome-wide association study (GWAS) meta …
[HTML][HTML] Acyl-lipid metabolism
Y Li-Beisson, B Shorrosh, F Beisson… - The Arabidopsis book …, 2013 - ncbi.nlm.nih.gov
Acyl lipids in Arabidopsis and all other plants have a myriad of diverse functions. These
include providing the core diffusion barrier of the membranes that separates cells and …
include providing the core diffusion barrier of the membranes that separates cells and …
[HTML][HTML] Exome-wide association study on alanine aminotransferase identifies sequence variants in the GPAM and APOE associated with fatty liver disease
O Jamialahmadi, RM Mancina, E Ciociola… - Gastroenterology, 2021 - Elsevier
Background & Aims Fatty liver disease (FLD) is a growing epidemic that is expected to be
the leading cause of end-stage liver disease within the next decade. Both environmental …
the leading cause of end-stage liver disease within the next decade. Both environmental …
Acyltransferases and transacylases that determine the fatty acid composition of glycerolipids and the metabolism of bioactive lipid mediators in mammalian cells and …
A Yamashita, Y Hayashi, Y Nemoto-Sasaki, M Ito… - Progress in lipid …, 2014 - Elsevier
Over one hundred different phospholipid molecular species are known to be present in
mammalian cells and tissues. Fatty acid remodeling systems for phospholipids including …
mammalian cells and tissues. Fatty acid remodeling systems for phospholipids including …
Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis
K Takeuchi, K Reue - American Journal of Physiology …, 2009 - journals.physiology.org
Triacylglycerol (TAG) synthesis and storage in tissues such as adipose tissue and liver have
important roles in metabolic homeostasis. The molecular identification of genes encoding …
important roles in metabolic homeostasis. The molecular identification of genes encoding …
Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signaling
RA Coleman, DG Mashek - Chemical reviews, 2011 - ACS Publications
Triacylglycerol (TAG) is the primary unit of energy storage in eukaryotic cells. TAG comprises
more than 90% of the content of white adipocytes, and TAG synthesis is essential in …
more than 90% of the content of white adipocytes, and TAG synthesis is essential in …
Therapeutic opportunities for the treatment of NASH with genetically validated targets
D Lindén, S Romeo - Journal of Hepatology, 2023 - Elsevier
The identification of genetic variants associated with fatty liver disease (FLD) from genome-
wide association studies started in 2008 when single nucleotide polymorphisms in PNPLA3 …
wide association studies started in 2008 when single nucleotide polymorphisms in PNPLA3 …
CC chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis
AE Obstfeld, E Sugaru, M Thearle, AM Francisco… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE Obesity induces a program of systemic inflammation that is implicated in the
development of many of its clinical sequelae. Hepatic inflammation is a feature of obesity …
development of many of its clinical sequelae. Hepatic inflammation is a feature of obesity …