Selenium as a bioactive micronutrient in the human diet and its cancer chemopreventive activity

D Radomska, R Czarnomysy, D Radomski… - Nutrients, 2021 - mdpi.com
This review answers the question of why selenium is such an important trace element in the
human diet. Daily dietary intake of selenium and its content in various food products is …

Selenium compounds as novel potential anticancer agents

D Radomska, R Czarnomysy, D Radomski… - International Journal of …, 2021 - mdpi.com
The high number of new cancer incidences and the associated mortality continue to be
alarming, leading to the search for new therapies that would be more effective and less …

Selenium nanoparticles overcomes sorafenib resistance in thioacetamide induced hepatocellular carcinoma in rats by modulation of mTOR, NF-κB pathways and …

TM Al-Noshokaty, NM Mesbah, DM Abo-Elmatty… - Life Sciences, 2022 - Elsevier
Aims The first-line treatment for advanced hepatocellular carcinoma (HCC) is the
multikinase inhibitor sorafenib (SOR). Sofafenib resistance is linked to protein kinase …

A summary of new findings on the biological effects of selenium in selected animal species—a critical review

B Hosnedlova, M Kepinska, S Skalickova… - International journal of …, 2017 - mdpi.com
Selenium is an essential trace element important for many physiological processes,
especially for the functions of immune and reproductive systems, metabolism of thyroid …

Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways

GK Azad, RS Tomar - Molecular biology reports, 2014 - Springer
Ebselen, an organoselenium compound, mimics glutathione peroxidase activity. It is a
multifunctional compound, which catalyzes several essential reactions for the protection of …

Importance of selenium and selenoprotein for brain function: From antioxidant protection to neuronal signalling

ND Solovyev - Journal of inorganic biochemistry, 2015 - Elsevier
Multiple biological functions of selenium manifest themselves mainly via 25 selenoproteins
that have selenocysteine at their active centre. Selenium is vital for the brain and seems to …

Selenium nanoparticles as a carrier of 5-fluorouracil to achieve anticancer synergism

W Liu, X Li, YS Wong, W Zheng, Y Zhang, W Cao… - ACS …, 2012 - ACS Publications
A simple method for preparing 5-fluorouracil surface-functionalized selenium nanoparticles
(5FU-SeNPs) with enhanced anticancer activity has been demonstrated in the present study …

Medicinal mushroom modulators of molecular targets as cancer therapeutics

BZ Zaidman, M Yassin, J Mahajna… - Applied Microbiology and …, 2005 - Springer
Empirical approaches to discover anticancer drugs and cancer treatments have made
limited progress in the past several decades in finding a cure for cancer. The expanded …

Selenium: a double-edged sword for defense and offence in cancer

J Brozmanová, D Mániková, V Vlčková… - Archives of toxicology, 2010 - Springer
Selenium (Se) is an essential dietary component for animals including humans and is
regarded as a protective agent against cancer. Although the mode of anticancer action of Se …

Positive surface charge enhances selective cellular uptake and anticancer efficacy of selenium nanoparticles

B Yu, Y Zhang, W Zheng, C Fan, T Chen - Inorganic chemistry, 2012 - ACS Publications
Surface charge plays a key role in cellular uptake and biological actions of nanomaterials.
Selenium nanoparticles (SeNPs) are novel Se species with potent anticancer activity and …