Oxidative stress and the role of redox signalling in chronic kidney disease
S Kishi, H Nagasu, K Kidokoro… - Nature Reviews …, 2024 - nature.com
Chronic kidney disease (CKD) is a major public health concern, underscoring a need to
identify pathogenic mechanisms and potential therapeutic targets. Reactive oxygen species …
identify pathogenic mechanisms and potential therapeutic targets. Reactive oxygen species …
Inhaled nitric oxide
B Yu, F Ichinose, DB Bloch… - British journal of …, 2019 - Wiley Online Library
Nitric oxide (NO) is a gas that induces relaxation of smooth muscle cells in the vasculature.
Because NO reacts with oxyhaemoglobin with high affinity, the gas is rapidly scavenged by …
Because NO reacts with oxyhaemoglobin with high affinity, the gas is rapidly scavenged by …
Effect of nitric oxide via cardiopulmonary bypass on ventilator-free days in young children undergoing congenital heart disease surgery: the NITRIC randomized …
LJ Schlapbach, KS Gibbons, SB Horton, K Johnson… - Jama, 2022 - jamanetwork.com
Importance In children undergoing heart surgery, nitric oxide administered into the gas flow
of the cardiopulmonary bypass oxygenator may reduce postoperative low cardiac output …
of the cardiopulmonary bypass oxygenator may reduce postoperative low cardiac output …
Acute kidney injury after cardiac surgery: prediction, prevention, and management
Acute kidney injury (AKI) is a common complication in cardiac surgery patients, with a
reported incidence of 20 to 30%. The development of AKI is associated with worse short-and …
reported incidence of 20 to 30%. The development of AKI is associated with worse short-and …
Hemolysis transforms liver macrophages into antiinflammatory erythrophagocytes
M Pfefferlé, G Ingoglia, CA Schaer… - The Journal of …, 2020 - Am Soc Clin Investig
During hemolysis, macrophages in the liver phagocytose damaged erythrocytes to prevent
the toxic effects of cell-free hemoglobin and heme. It remains unclear how this homeostatic …
the toxic effects of cell-free hemoglobin and heme. It remains unclear how this homeostatic …
Nitric oxide: clinical applications in critically ill patients
Inhaled nitric oxide (iNO) acts as a selective pulmonary vasodilator and it is currently
approved by the FDA for the treatment of persistent pulmonary hypertension of the newborn …
approved by the FDA for the treatment of persistent pulmonary hypertension of the newborn …
[HTML][HTML] Nitric oxide delivery during cardiopulmonary bypass reduces acute kidney injury: A randomized trial
NO Kamenshchikov, YJ Anfinogenova… - The Journal of Thoracic …, 2022 - Elsevier
Objective Acute kidney injury (AKI) is a serious complication of cardiac surgery with
cardiopulmonary bypass (CPB). The aim of this study was to evaluate the effects of nitric …
cardiopulmonary bypass (CPB). The aim of this study was to evaluate the effects of nitric …
[HTML][HTML] Inhaled pulmonary vasodilators: a narrative review
K Liu, H Wang, SJ Yu, GW Tu, Z Luo - Annals of Translational …, 2021 - ncbi.nlm.nih.gov
Pulmonary hypertension (PH) is a severe disease that affects people of all ages. It can occur
as an idiopathic disorder at birth or as part of a variety of cardiovascular and pulmonary …
as an idiopathic disorder at birth or as part of a variety of cardiovascular and pulmonary …
Inorganic nitrate benefits contrast-induced nephropathy after coronary angiography for acute coronary syndromes: the NITRATE-CIN trial
DA Jones, AM Beirne, M Kelham, L Wynne… - European Heart …, 2024 - academic.oup.com
Abstract Background and Aims Contrast-induced nephropathy (CIN), also known as contrast-
associated acute kidney injury (CA-AKI) underlies a significant proportion of the morbidity …
associated acute kidney injury (CA-AKI) underlies a significant proportion of the morbidity …
Nitric oxide in cardiac surgery: a review article
NO Kamenshchikov, N Duong, L Berra - Biomedicines, 2023 - mdpi.com
Perioperative organ injury remains a medical, social and economic problem in cardiac
surgery. Patients with postoperative organ dysfunction have increases in morbidity, length of …
surgery. Patients with postoperative organ dysfunction have increases in morbidity, length of …