Background Neurological diseases seriously affect human health, which are arousing wider
attention, and it is a great challenge to discover neuroprotective drugs with minimal side …

As human life expectancy increases, cognitive decline and memory impairment threaten
independence and quality of life. Therefore, finding prevention and treatment strategies for …

The endogenous cannabinoid transmitter system regulates synaptic transmission
throughout the nervous system. Unlike conventional transmitters, specific stimuli induce …

It is hard to overestimate the influence of the endocannabinoid signaling (ECS) system on
central nervous system (CNS) function. In the 40 years since cannabinoids were found to …

Microglia, the innate immune cells of the central nervous system (CNS), execute their
sentinel, housekeeping and defense functions through a panoply of genes, receptors and …

Brain iron overload is positively correlated with the pathogenesis of Alzheimer's disease
(AD). However, the role of iron in AD pathology is not completely understood. Furin is the …

Early-life adverse experiences (first hit) lead to coping strategies that may confer resilience
or vulnerability to later experienced stressful events (second hit) and the subsequent …

Millions of residents in areas with high-fluoride drinking water supply ingest excessive levels
of fluoride for long periods. This study investigated the mechanisms and impacts of lifelong …

Anxiety or depression after percutaneous coronary intervention (PCI) is one of the key
clinical problems in cardiology that need to be solved urgently. Brain-derived neurotrophic …

Glucocorticoids are primary stress hormones that exert neuronal effects via both genomic
and non-genomic signaling pathways. However, their rapid non-genomic effects and …