Hereditary spastic paraplegia (HSP) is a rare neurodegenerative disorder with the
predominant clinical manifestation of spasticity in the lower extremities. HSP is categorised …

Inherited neurodegenerative pathology characterized by lower muscle tone and increasing
spasticity in the lower limbs is termed hereditary spastic paraplegia (HSP). HSP is …

One of the first molecular events in neurodegenerative diseases, regardless of etiology, is
protein mislocalization. Protein mislocalization in neurons is often linked to proteostasis …

The endoplasmic reticulum (ER) is the most abundant and widespread organelle in cells. Its
peculiar membrane architecture, formed by an intricate network of tubules and cisternae, is …

Objectives Hereditary spastic paraplegia (HSP) is a group of genetic neurodegenerative
diseases characterised by upper motor neuron (UMN) impairment of the lower limbs. The …

Hereditary spastic paraplegia (HSP) is a heterogeneous group of genetic
neurodegenerative disorders, characterized by progressive lower limb spasticity and …

Hereditary spastic paraplegia type 15 (HSP15) is a neurodegenerative condition caused by
the inability to produce SPG15 protein, which leads to lysosomal swelling. However, the link …

Hereditary spastic paraplegias (HSPs) are a group of inherited, progressive
neurodegenerative conditions characterised by prominent lower-limb spasticity and …

Abstract DEAD-box helicase 53 (DDX53) is a member of the DEAD-box protein family of
RNA helicases. Unlike other family members that are responsible for RNA metabolism, the …

Hereditary spastic paraplegia is a genetically heterogeneous neurodegenerative disorder
characterised primarily by muscle stiffness in the lower limbs. Neurodegenerative disorders …