Cells translate extracellular signals to regulate processes such as differentiation,
metabolism and proliferation, via transmembranar receptors. G protein-coupled receptors …

Many different intrinsically disordered proteins and proteins with intrinsically disordered
regions are associated with neurodegenerative diseases. These types of proteins including …

We quantified genome-wide patterns of lysine H3K27 acetylation (H3K27ac) in entorhinal
cortex samples from Alzheimer's disease (AD) cases and matched controls using chromatin …

Volatile organic compounds (VOCs) are gaseous chemicals found in ambient air and
exhaled breath. In particular, highly reactive aldehydes are frequently found in polluted air …

Background Genotypes are strongly associated with disease phenotypes, particularly in
brain disorders. However, the molecular and cellular mechanisms behind this association …

Biased G protein–coupled receptor (GPCR) ligands, which preferentially activate G protein
or β-arrestin signaling pathways, are leading to the development of drugs with superior …

Highlights•GPCRs are implicated in the pathophysiology of various neurodegenerative
diseases.•Currently available therapies do not cure the discussed neurodegenerative …

Cell surface receptors are important proteins that mediate communication between the cells
and their outside environment, and also play essential roles in the control of a wide variety of …

Due to the aging population in the world, neurodegenerative diseases have become a
serious public health issue that greatly impacts patients' quality of life and adds a huge …

Obesity has a noteworthy role in breast tumor initiation and progression. Among the
mechanisms proposed, the most validated is the development of chronic low-grade …