Self-emulsifying drug delivery systems: An alternative approach to improve brain bioavailability of poorly water-soluble drugs through intranasal administration
S Meirinho, M Rodrigues, AO Santos, A Falcão… - Pharmaceutics, 2022 - mdpi.com
Efforts in discovering new and effective neurotherapeutics are made daily, although most fail
to reach clinical trials. The main reason is their poor bioavailability, related to poor aqueous …
to reach clinical trials. The main reason is their poor bioavailability, related to poor aqueous …
Self-Generating nano-emulsification techniques for alternatively-routed, bioavailability enhanced delivery, especially for anti-cancers, anti-diabetics, and …
The self-generating nano-emulsifying drug delivery system (SNEDDS) is among the most
effective approaches to enhance the oral bioavailability of a therapeutic agent, especially of …
effective approaches to enhance the oral bioavailability of a therapeutic agent, especially of …
Design and optimization of candesartan loaded self-nanoemulsifying drug delivery system for improving its dissolution rate and pharmacodynamic potential
During the last decades, much attention has been focused on SNEDDS approach to resolve
concerns of BCS II class drugs with accentuation on upgrading the solubility and …
concerns of BCS II class drugs with accentuation on upgrading the solubility and …
Nanoparticles of a pyrazolo-pyridazine derivative as potential EGFR and CDK-2 inhibitors: design, structure determination, anticancer evaluation and in silico studies
The strategic planning of this study is based upon using the nanoformulation method to
prepare nanoparticles 4-SLNs and 4-LPHNPs of the previously prepared 4, 5-diphenyl-1 H …
prepare nanoparticles 4-SLNs and 4-LPHNPs of the previously prepared 4, 5-diphenyl-1 H …
Investigating the Impact of Optimized Trans-Cinnamic Acid-Loaded PLGA Nanoparticles on Epithelial to Mesenchymal Transition in Breast Cancer
NM Badawi, YM Attia, DM El-Kersh… - International Journal …, 2022 - Taylor & Francis
Purpose To design and optimize trans-cinnamic acid-loaded PLGA nanoparticles (CIN-
PLGA-NPs) and assess its inhibitory effect on epithelial-mesenchymal transition (EMT) in …
PLGA-NPs) and assess its inhibitory effect on epithelial-mesenchymal transition (EMT) in …
PEG-poly (amino acid) s/EpCAM aptamer multifunctional nanoparticles arrest the growth and metastasis of colorectal cancer
Tanshinone II-A (TSIIA) is a derivative of a phenanthrene-quinone extracted from a TCM
herb, Salvia miltiorrhiza, and has been widely adopted in the treatment of colorectal cancer …
herb, Salvia miltiorrhiza, and has been widely adopted in the treatment of colorectal cancer …
Enabling oral delivery of antiviral drugs: Double emulsion carriers to improve the intestinal absorption of zanamivir
N Debotton, S Garsiani, Y Cohen, A Dahan - International Journal of …, 2022 - Elsevier
Antiviral drugs play a major role in the control of seasonal influenza epidemics and may
provide prophylactic and therapeutic benefits during an eventual pandemic. Among the …
provide prophylactic and therapeutic benefits during an eventual pandemic. Among the …
Quality-by-design strategy for the development of arteether loaded solid self-micro emulsifying drug delivery systems
The present work is conducted to develop the innovative micro sized solid oral dosage forms
of Arteether using a Quality by Design technique to increase the solubility and …
of Arteether using a Quality by Design technique to increase the solubility and …
Genes associated with altered brain structure and function in obstructive sleep apnea
Y Huang, C Shen, W Zhao, Y Shang, Y Wang… - Biomedicines, 2023 - mdpi.com
Obstructive sleep apnea (OSA) has been widely reported to cause abnormalities in brain
structure and function, but the genetic mechanisms behind these changes remain largely …
structure and function, but the genetic mechanisms behind these changes remain largely …
Dissolution and antioxidant potential of apigenin self nanoemulsifying drug delivery system (SNEDDS) for oral delivery
B Morakul, V Teeranachaideekul, W Limwikrant… - Scientific Reports, 2024 - nature.com
Self-nanoemulsifying drug delivery systems (SNEDDS) have been used to improve the oral
bioavailability of various drugs. In the current study, apigenin was developed as SNEDDS to …
bioavailability of various drugs. In the current study, apigenin was developed as SNEDDS to …