The promising interplay between sonodynamic therapy and nanomedicine
Sonodynamic therapy (SDT) is a non-invasive approach for cancer treatment in which
chemical compounds, named sonosensitizers, are activated by non-thermal ultrasound …
chemical compounds, named sonosensitizers, are activated by non-thermal ultrasound …
[HTML][HTML] Replacement, reduction, and refinement of animal experiments in anticancer drug development: the contribution of 3D in vitro cancer models in the drug …
In the last decades three-dimensional (3D) in vitro cancer models have been proposed as a
bridge between bidimensional (2D) cell cultures and in vivo animal models, the gold …
bridge between bidimensional (2D) cell cultures and in vivo animal models, the gold …
[HTML][HTML] From 2D to 3D cancer cell models—the enigmas of drug delivery research
Over the past decades, research has made impressive breakthroughs towards drug delivery
systems, resulting in a wide range of multifunctional engineered nanoparticles with …
systems, resulting in a wide range of multifunctional engineered nanoparticles with …
A comprehensive review on 3D tissue models: Biofabrication technologies and preclinical applications
R Xie, V Pal, Y Yu, X Lu, M Gao, S Liang, M Huang… - Biomaterials, 2023 - Elsevier
The limitations of traditional two-dimensional (2D) cultures and animal testing, when it
comes to precisely foreseeing the toxicity and clinical effectiveness of potential drug …
comes to precisely foreseeing the toxicity and clinical effectiveness of potential drug …
Monolayer (2D) or spheroids (3D) cell cultures for nanotoxicological studies? Comparison of cytotoxicity and cell internalization of nanoparticles
Abstract Two-dimensional (2D) cell culture monolayers are commonly used for toxicological
assessments of nanomaterials. Despite their facile handling, they exhibit several constraints …
assessments of nanomaterials. Despite their facile handling, they exhibit several constraints …
Advances in 3D culture systems for therapeutic discovery and development in brain cancer
Highlights•Existing models for drug discovery and development against glioblastoma
multiforme (GBM) have limitations.•We review advances in 3D systems that promise more …
multiforme (GBM) have limitations.•We review advances in 3D systems that promise more …
Organoid technology: Current standing and future perspectives
L Shariati, Y Esmaeili, S Haghjooy Javanmard… - Stem Cells, 2021 - academic.oup.com
Organoids are powerful systems to facilitate the study of individuals' disorders and
personalized treatments. This emerging technology has improved the chance of …
personalized treatments. This emerging technology has improved the chance of …
[HTML][HTML] Cancer immunotherapy dosing: a pharmacokinetic/pharmacodynamic perspective
F Le Louedec, F Leenhardt, C Marin, É Chatelut… - Vaccines, 2020 - mdpi.com
Immune check-point inhibitors are drugs that are markedly different from other anticancer
drugs because of their indirect mechanisms of antitumoral action and their apparently …
drugs because of their indirect mechanisms of antitumoral action and their apparently …
[HTML][HTML] Three-Dimensional (3D) in vitro cell culture protocols to enhance glioblastoma research
Three-dimensional (3D) cell culture models can help bridge the gap between in vitro cell
cultures and in vivo responses by more accurately simulating the natural in vivo …
cultures and in vivo responses by more accurately simulating the natural in vivo …
[HTML][HTML] Nanobiotechnological approaches for breast cancer Management: Drug delivery systems and 3D In-Vitro models
The science of nanotechnology has been proposed as a factor of main change in the field of
cancer diagnosis and treatment. The challenges in common clinical treatment of breast …
cancer diagnosis and treatment. The challenges in common clinical treatment of breast …