How the PhoP/PhoQ System Controls Virulence and Mg2+ Homeostasis: Lessons in Signal Transduction, Pathogenesis, Physiology, and Evolution
SUMMARY The PhoP/PhoQ two-component system governs virulence, Mg2+ homeostasis,
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …
Evolution of two-component signal transduction systems
To exist in a wide range of environmental niches, bacteria must sense and respond to a
variety of external signals. A primary means by which this occurs is through two-component …
variety of external signals. A primary means by which this occurs is through two-component …
The biology of the PmrA/PmrB two-component system: the major regulator of lipopolysaccharide modifications
HD Chen, EA Groisman - Annual review of microbiology, 2013 - annualreviews.org
The ability of gram-negative bacteria to resist killing by antimicrobial agents and to avoid
detection by host immune systems often entails modification to the lipopolysaccharide (LPS) …
detection by host immune systems often entails modification to the lipopolysaccharide (LPS) …
Directed networks reveal genomic barriers and DNA repair bypasses to lateral gene transfer among prokaryotes
Lateral gene transfer (LGT) plays a major role in prokaryote evolution with only a few genes
that are resistant to it; yet the nature and magnitude of barriers to lateral transfer are still …
that are resistant to it; yet the nature and magnitude of barriers to lateral transfer are still …
An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors
Transcription factors (TFs) play key roles in both development and stress responses. By
integrating into and rewiring original systems, novel TFs contribute significantly to the …
integrating into and rewiring original systems, novel TFs contribute significantly to the …
Bacterial transcription as a target for antibacterial drug development
Transcription, the first step of gene expression, is carried out by the enzyme RNA
polymerase (RNAP) and is regulated through interaction with a series of protein transcription …
polymerase (RNAP) and is regulated through interaction with a series of protein transcription …
Genomic characterization of the Bacillus cereus sensu lato species: backdrop to the evolution of Bacillus anthracis
The key genes required for Bacillus anthracis to cause anthrax have been acquired recently
by horizontal gene transfer. To understand the genetic background for the evolution of B …
by horizontal gene transfer. To understand the genetic background for the evolution of B …
When is a transcription factor a NAP?
Highlights•Addresses the nature of the distinction between bacterial transcription factors and
nucleoid-associated proteins.•Proteins lie along a spectrum of influence extending from …
nucleoid-associated proteins.•Proteins lie along a spectrum of influence extending from …
ArcS, the Cognate Sensor Kinase in an Atypical Arc System of Shewanella oneidensis MR-1
J Lassak, AL Henche, L Binnenkade… - Applied and …, 2010 - Am Soc Microbiol
The availability of oxygen is a major environmental factor for many microbes, in particular for
bacteria such as Shewanella species, which thrive in redox-stratified environments. One of …
bacteria such as Shewanella species, which thrive in redox-stratified environments. One of …
DNA Damage Triggers Genetic Exchange in Helicobacter pylori
MS Dorer, J Fero, NR Salama - PLoS pathogens, 2010 - journals.plos.org
Many organisms respond to DNA damage by inducing expression of DNA repair genes. We
find that the human stomach pathogen Helicobacter pylori instead induces transcription and …
find that the human stomach pathogen Helicobacter pylori instead induces transcription and …