Cardiovascular diseases (CVDs) stand as the leading cause of death worldwide, posing a
significant global health challenge. Consequently, the development of innovative …

Gynecologic cancers, including ovarian cancer (OC), cervical cancer (CC), and endometrial
cancer (EC), pose a serious threat to women's health and quality of life due to their high …

Significance: Cholesterol plays a crucial role in brain, where it is highly concentrated and
tightly regulated to support normal brain functions. It serves as a vital component of cell …

Background Gout is a prevalent manifestation of metabolic osteoarthritis induced by
elevated blood uric acid levels. The purpose of this study was to investigate the mechanisms …

Circular RNAs (circRNAs) showing unusual expressions have been discovered in
pancreatic adenocarcinoma (PAAD). However, the functions and underlying mechanisms of …

Background Oculomotor nerve palsy (ONP) is a neuroparalytic disorder resulting in
dysfunction of innervating extraocular muscles (EOMs), of which the pathological …

Fatty liver hemorrhagic syndrome (FLHS) is the most common metabolic disease in laying
hens. Morus alba L.(mulberry) leaf has the effect of regulating lipid metabolism. We …

Squalene epoxidase (SQLE) is a key enzyme in the mevalonate–cholesterol pathway that
plays a critical role in cellular physiological processes. It converts squalene to 2, 3 …

Background Sevoflurane is a widely used anesthetic in infants. However, long and repeated
exposure to this drug can cause developmental neurotoxicity. This study aimed to …

Obesity results in hepatic fat accumulation, ie, steatosis. In addition to fat overload, impaired
fatty acid β-oxidation also promotes steatosis. Fatty acid β-oxidation takes place in the …