The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

The presence of epoxyeicosatrienoic acids (EETs) in tissues and their metabolism by
soluble epoxide hydrolase (sEH) to 1, 2-diols were first reported 30 years ago. However …

This report describes the development of an orally active analgesic that resolves
inflammation and neuropathic pain without the addictive potential of opioids. EC5026 acts …

Eicosanoids are biologically active lipid signaling molecules derived from polyunsaturated
fatty acids. Many of the actions of eicosanoid metabolites formed by cyclooxygenase and …

Numerous benefits have been attributed to dietary long-chain omega-3 polyunsaturated fatty
acids (n-3 LC-PUFAs), including protection against cardiac arrhythmia, triglyceride-lowering …

The cardiovascular effects of epoxyeicosatrienoic acids (EETs) include vasodilation,
antimigratory actions on vascular smooth muscle cells and anti-inflammatory actions. These …

Polyunsaturated fatty acids (PUFA) are oxidized by cytochrome P450 epoxygenases to
PUFA epoxides which function as potent lipid mediators. The major metabolic pathways of …

Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly
contribute to vascular and cardiac physiology. The contribution of EETs to vascular and …

Originally regarded as just membrane constituents and energy storing molecules, lipids are
now recognised as potent signalling molecules that regulate a multitude of cellular …

Before we discuss lipids and their role in homeostasis and host defense, we will recount the
essence of the inflammatory response. Inflammation is a reaction of the microcirculation; it's …