Cells are continually exposed to reactive oxygen species (ROS) generated during cellular
metabolism. Apoptosis, necrosis, and autophagy are biological processes involving a …

In the open metabolic system, redox-related signaling requires continuous monitoring and
fine-tuning of the steady-state redox set point. The ongoing oxidative metabolism is a …

SLC7A11-mediated cystine uptake suppresses ferroptosis yet promotes cell death under
glucose starvation; the nature of the latter cell death remains unknown. Here we show that …

S-glutathionylation and S-nitrosylation are reversible post-translational modifications on the
cysteine thiol groups of proteins, which occur in cells under physiological conditions and …

Glutathione (GSH) is the most abundant cellular tripeptide (L‐γ‐glutamate‐L‐cysteinyl‐
glycine) which is as critical as oxygen and water. This low molecular mass antioxidant has a …

Elevation of reactive oxygen species (ROS) levels is a general consequence of tumor cells'
response to treatment and may cause tumor cell death. Mechanisms by which tumor cells …

Glutathione (GSH) is a ubiquitous tripeptide that is biosynthesized in situ at high
concentrations (1–5 mM) and involved in the regulation of cellular homeostasis via multiple …

Both environmental exposure to vanadium pentoxide (V 2 O 5, V+ 5 for its ionic
counterparts) and fibroblast senescence are associated with pulmonary fibrosis, but whether …

From bacteria to plants and humans, the glutathione system plays a pleiotropic role in cell
defense against metabolic, oxidative and metal stresses. Glutathione (GSH), the γ-L …

Redox biology is a very quickly developing area of modern biological sciences, and roles of
redox homeostasis in health and disease have recently received tremendous attention …