Cancer cells display pervasive changes in DNA methylation, disrupted patterns of histone
posttranslational modification, chromatin composition or organization and regulatory …

Acute myeloid leukemia (AML) is a hematological malignancy resulting from the genetic
alterations and epigenetic dysregulations of the hematopoietic progenitor cells. One-third of …

Despite the development of novel therapies for acute myeloid leukemia, outcomes remain
poor for most patients, and therapeutic improvements are an urgent unmet need. Although …

Nucleophosmin-1 (NPM1) is a pleiotropic protein involved in numerous cellular processes.
NPM1 shuttles between the nucleus and the cytoplasm, but exhibits a predominant …

Cancer is the second leading cause of death worldwide, accounting for approximately 10
million deaths in 2020. A huge number of effective target therapies have been developed …

Interest in the use of proteolysis-targeting chimeras (PROTACs) in cancer therapy has
increased in recent years. Targeting bromodomain and extra terminal domain (BET) …

Despite the development of novel therapies for acute myeloid leukemia (AML), outcomes
remain poor for most patients, and therapeutic improvements are an urgent unmet need …