Nonhuman primates are critically important animal models in which to study complex human
diseases, understand biological functions, and address the safety of new diagnostics and …

The HIV-1 capsid, a conical shell encasing viral nucleoprotein complexes, is involved in
multiple post-entry processes during viral replication. Many host factors can directly bind to …

Although genome editing technologies have the potential to revolutionize the way we treat
human diseases, barriers to successful clinical implementation remain. Increasingly …

Non-human primates (NHPs) are the most relevant model of Acquired Immunodeficiency
Syndrome (AIDS) and neuroAIDS, being of great importance in explaining the pathogenesis …

A major barrier in the use of humanized mice as models of HIV-1 (HIV) infection is the
inadequate generation of virus-specific antibody responses. Humanized DRAGA (hDRAGA) …

Sexually transmitted HIV infections in heterosexual men are acquired through the penis.
Low adherence to condom usage and the fact that 40% of circumcised men are not …

Although a wide variety of topical microbicides provide promising in vitro and in vivo efficacy,
most of them failed to prevent sexual transmission of human immunodeficiency virus type 1 …

People living with HIV and who receive antiretroviral therapy have a significantly improved
lifespan, compared to the early days without therapy. Unfortunately, persisting viral …

Chronic Human Immunodeficiency Virus (HIV) infection remains a significant challenge to
global public health. Despite advances in antiretroviral therapy (ART), which has …

Human immunodeficiency virus (HIV), the main contributor of the ongoing AIDS epidemic,
remains one of the most challenging and complex viruses to target and eradicate due to …