BACKGROUND Within the antral follicle, the oocyte is reliant on metabolic support from its
surrounding somatic cells. Metabolism plays a critical role in oocyte developmental …

The participation of extracellular vesicles in many cellular processes, including reproduction,
is unquestionable. Although currently, the tetraspanin proteins found in extracellular vesicles …

Bidirectional somatic cell–oocyte signaling is essential to create a changing intrafollicular
microenvironment that controls primordial follicle growth into a cohort of growing follicles …

The environment that the cumulus oocyte complex (COC) is exposed to during either in vivo
or in vitro maturation (IVM) can have profound effects on the success of fertilisation and …

Oocyte and embryo metabolism are closely linked with their subsequent developmental
capacity. Lipids are a potent source of cellular energy, yet little is known about lipid …

Proper physiological function of the ovaries is very important for the entire female
reproductive system and overall health. Reactive oxygen species (ROS) are generated as …

Producing high-competent oocytes during the in vitro maturation (IVM) is considered a key
step for the success of the in vitro production (IVP) of embryos. One of the known disruptors …

Our current perspectives on the relationship between the oocyte and its surrounding somatic
cells are changing as we gain a greater understanding of factors regulating folliculogenesis …

Successful ovulation requires that developmentally competent oocytes are released with
appropriate timing from the ovarian follicle. Somatic cells of the follicle sense the ovulatory …

BACKGROUND Oocyte in vitro maturation (IVM) reduces the need for gonadotrophin-
induced ovarian hyperstimulation and its associated health risks but the unacceptably low …