Dysregulation of the gut microbiome has been implicated in the progression of many
diseases. This study explored the role of microbial and metabolic signatures, and their …

Background Immune-mediated inflammatory diseases (IMIDs) are a group of several chronic
disorders with elusive pathogenesis that results in dysregulation of the normal immune …

Simple Summary Cancer is one of the leading causes of death worldwide. Colorectal cancer
belongs to the group of the most malignant tumors for which their burden can be only …

Crohn's disease is an inflammatory bowel disease (IBD) which most often presents with
patchy lesions in the terminal ileum and colon and requires complex clinical care. Recent …

Pediatric Crohn's disease (CD) is characterized by a severe disease course with frequent
complications. We sought to apply machine learning-based models to predict risk of …

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A critical challenge in analyzing multi-omics data from clinical cohorts is the re-use of these
valuable datasets to answer biological questions beyond the scope of the original study …

Background: Pediatric inflammatory bowel disease (IBD) is a chronic inflammatory intestinal
disease that affects both children and adolescents. Symptoms can significantly affect a …

A mutualistic relationship between the composition, function and activity of the gut
microbiota (GM) and the host exists, and the alteration of GM, sometimes referred as …

Despite the evolving therapeutic armamentarium, the treatment of IBD patients remains
challenging and many patients fail to respond to biologic agents. With the limited yield of …