Apoptosis ligand 2 tumor necrosis factor (TNF)-related apoptosis-inducing ligand
(Apo2L/TRAIL) belongs to a small subset of proapoptotic protein ligands in the TNF …

CD 95 (also known as Fas) is a member of the tumor necrosis factor receptor (TNFR)
superfamily. Its cognate ligand, CD 95L, is implicated in immune homeostasis and immune …

Endothelial cells lining new blood vessels that develop during inflammatory disorders or
cancers act as doors that either allow or block access to the tumor or inflamed organ. Recent …

CD95 (also known as Fas) is the prototype of death receptors; however, evidence suggests
that this receptor mainly implements non-apoptotic signaling pathways such as NF-κB …

Apoptosis is a fundamental process that contributes to tissue homeostasis, immune
responses, and development. The receptor CD95, also called Fas, is a member of the tumor …

Metalloprotease-processed CD95L (cl-CD95L) is a soluble cytokine that implements a
PI3K/Ca 2+ signaling pathway in triple-negative breast cancer (TNBC) cells. Accordingly …

The death receptor CD95 plays a pivotal role in immune surveillance and immune tolerance.
Binding of CD95L to CD95 leads to recruitment of the adaptor protein Fas-associated death …

Constitutive activation of the PI3K/mTOR signaling pathway contributes to carcinogenesis
and metastasis in most, if not all, breast cancers. From a chromene backbone reported to …

Abstract CD95 (Apo1/Fas) has been originally identified as the target of cell death-inducing
antibodies. The recognition of CD95 as an apoptosis-triggering receptor represents one of …

We have addressed complex formation between the death domain (DD) of the death
receptor CD95 (Fas/APO-1) with the DD of immediate adaptor protein FADD using nuclear …