Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …

Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …

Neuropathic pain is triggered by lesions to the somatosensory nervous system that alter its
structure and function so that pain occurs spontaneously and responses to noxious and …

Glia have emerged as key contributors to pathological and chronic pain mechanisms. On
activation, both astrocytes and microglia respond to and release a number of signalling …

Neuropathic pain refers to pain that originates from pathology of the nervous system.
Diabetes, infection (herpes zoster), nerve compression, nerve trauma," channelopathies," …

This review is focused on purinergic neurotransmission, ie, ATP released from nerves as a
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …

Millions of people worldwide suffer from neuropathic pain as a result of damage to or
dysfunction of the nervous system under various disease conditions. Development of …

Recent findings indicate that neurons are not merely passive targets of microglia but rather
control microglial activity. The variety of different signals that neurons use to control …

In contrast to physiological pain, pathological pain is not dependent on the presence of
tissue‐damaging stimuli. One type of pathological pain–neuropathic pain–is often a …

Microglia are the intrinsic immune cells of the brain and express chemokine and cytokine
receptors that interact with the peripheral immune cells. Recent studies have indicated that …