[HTML][HTML] Systematic review and meta-analysis on microRNAs in amyotrophic lateral sclerosis

H Liu, S Lan, XJ Shi, FC Fan, QS Liu, L Cong… - Brain Research …, 2023 - Elsevier
MicroRNAs (miRNAs) exhibit a crucial role in the pathogenesis and progress of
neurodegenerative disorders. Recent studies have shown abnormal levels of miRNA …

Unveiling the role of gut-brain axis in regulating neurodegenerative diseases: A comprehensive review

H Yadav, R Bhardwaj, A Bakshi, S Gupta, SK Maurya - Life Sciences, 2023 - Elsevier
Emerging evidence have shown the importance of gut microbiota in regulating brain
functions. The diverse molecular mechanisms involved in cross-talk between gut and brain …

Small extracellular vesicles' miRNAs: biomarkers and therapeutics for neurodegenerative diseases

WQ Lim, KH Michelle Luk, KY Lee, N Nurul, SJ Loh… - Pharmaceutics, 2023 - mdpi.com
Neurodegenerative diseases are critical in the healthcare system as patients suffer from
progressive diseases despite currently available drug management. Indeed, the growing …

Neurotoxic astrocytes directly converted from sporadic and familial ALS patient fibroblasts reveal signature diversities and miR-146a theragnostic potential in specific …

C Gomes, C Sequeira, S Likhite, CN Dennys, SJ Kolb… - Cells, 2022 - mdpi.com
A lack of stratification methods in patients with amyotrophic lateral sclerosis (ALS) is likely
implicated in therapeutic failures. Regional diversities and pathophysiological abnormalities …

Exosomes in brain diseases: Pathogenesis and therapeutic targets

Q Si, L Wu, D Pang, P Jiang - MedComm, 2023 - Wiley Online Library
Exosomes are extracellular vesicles with diameters of about 100 nm that are naturally
secreted by cells into body fluids. They are derived from endosomes and are wrapped in …

Depressive symptoms as mediator on the link between physical activity and cognitive function: Longitudinal evidence from older adults in China

J Liu, F Qiang, J Dang, Q Chen - Clinical Gerontologist, 2023 - Taylor & Francis
Objectives This study examines the extent to which depressive symptoms mediate the link
between physical activity and cognitive function among older adults in China. Methods This …

Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer's disease

G Cui, J Zhu, Y Wang, J Wu, J Liu, H Guo - Mechanisms of Ageing and …, 2021 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease. Exosomes are
extracellular vesicles secreted by a variety of cells, and they participate in intercellular …

Cerebrospinal fluid and blood exosomes as biomarkers for amyotrophic lateral sclerosis; a systematic review

S Darabi, A Ariaei, A Rustamzadeh, D Afshari… - Diagnostic …, 2024 - Springer
Background Amyotrophic lateral sclerosis (ALS) is a progressive and fatal motor neuron
disease. Due to the limited knowledge about potential biomarkers that help in early …

Recent advances in delivery of peptide and protein therapeutics to the brain

S Arora, T Bajaj, J Kumar, M Goyal, A Singh… - Journal of Pharmacology …, 2024 - ASPET
The classes of neuropharmaceuticals known as proteins and peptides serve as diagnostic
tools and are involved in specific communication in the peripheral and central nervous …

Extracellular vesicles: A new paradigm in understanding, diagnosing and treating neurodegenerative disease

GH Dar, R Badierah, EG Nathan, MA Bhat… - Frontiers in Aging …, 2022 - frontiersin.org
Neurodegenerative disorders (NDs) are becoming one of the leading causes of disability
and death across the globe due to lack of timely preventions and treatments. Concurrently …