Respiratory epithelial cell responses to SARS-CoV-2 in COVID-19

JP Bridges, EK Vladar, H Huang, RJ Mason - Thorax, 2022 - thorax.bmj.com
COVID-19 has different clinical stages, and effective therapy depends on the location and
extent of the infection. The purpose of this review is to provide a background for …

Mucosal immunity: The missing link in comprehending SARS-CoV-2 infection and transmission

MW Russell, J Mestecky - Frontiers in immunology, 2022 - frontiersin.org
SARS-CoV-2 is primarily an airborne infection of the upper respiratory tract, which on
reaching the lungs causes the severe acute respiratory disease, COVID-19. Its first contact …

A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic

T Shapira, IA Monreal, SP Dion, DW Buchholz… - Nature, 2022 - nature.com
The COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health
crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced …

[HTML][HTML] SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming

CT Wu, PV Lidsky, Y Xiao, R Cheng, IT Lee… - Cell, 2023 - cell.com
How SARS-CoV-2 penetrates the airway barrier of mucus and periciliary mucins to infect
nasal epithelium remains unclear. Using primary nasal epithelial organoid cultures, we …

Phase III Pivotal comparative clinical trial of intranasal (iNCOVACC) and intramuscular COVID 19 vaccine (Covaxin®)

C Singh, S Verma, P Reddy, MS Diamond, DT Curiel… - npj Vaccines, 2023 - nature.com
One of the most preferable characteristics for a COVID-19 vaccine candidate is the ability to
reduce transmission and infection of SARS-CoV-2, in addition to disease prevention. Unlike …

COVID-19 intranasal vaccines: current progress, advantages, prospects, and challenges

K Dhama, M Dhawan, R Tiwari, TB Emran… - Human vaccines & …, 2022 - Taylor & Francis
Multiple vaccines have recently been developed, and almost all the countries are presently
vaccinating their population to tackle the COVID-19 pandemic. Most of the COVID-19 …

Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention

E Shirbhate, J Pandey, VK Patel, M Kamal… - Pharmacological …, 2021 - Springer
Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with
hypertension, renin–angiotensin–aldosterone system pathway, and other cardiovascular …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2021 - Wiley Online Library
The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

Close proximity risk assessment for SARS-CoV-2 infection

G Cortellessa, L Stabile, F Arpino, DE Faleiros… - Science of The Total …, 2021 - Elsevier
Although the interpersonal distance represents an important parameter affecting the risk of
infection due to respiratory viruses, the mechanism of exposure to exhaled droplets remains …

Upper respiratory tract mucosal immunity for SARS-CoV-2 vaccines

R Fraser, A Orta-Resendiz, A Mazein… - Trends in molecular …, 2023 - cell.com
SARS-CoV-2 vaccination significantly reduces morbidity and mortality, but has less impact
on viral transmission rates, thus aiding viral evolution, and the longevity of vaccine-induced …