The regulative capability of single cells to give rise to all primary embryonic lineages is
termed pluripotency. Observations of fluctuating gene expression and phenotypic …

Pluripotency is the remarkable capacity of a single cell to engender all the specialized cell
types of an adult organism. This property can be captured indefinitely through derivation of …

Embryonic stem cells (ESCs) of mice and humans have distinct molecular and biological
characteristics, raising the question of whether an earlier," naive" state of pluripotency may …

Much attention has focussed on the conversion of human pluripotent stem cells (PSCs) to a
more naïve developmental status. Here we provide a method for resetting via transient …

Pluripotent stem cells constitute a platform to model disease and developmental processes
and can potentially be used in regenerative medicine. However, not all pluripotent cell lines …

The common marmoset (C allithrix jacchus) is a small N ew W orld primate; it originally
comes from the A tlantic coastal forests in northeastern B razil. It has been attracting much …

Leukemia inhibitory factor (LIF)/STAT3 signalling is a hallmark of naive pluripotency in
rodent pluripotent stem cells (PSCs), whereas fibroblast growth factor (FGF)-2 and …

Cell banking, disease modeling, and cell therapy applications have placed increasing
demands on hiPSC technology. Specifically, the high-throughput derivation of footprint-free …

A simplified and cost-effective culture system for maintaining the pluripotency of human
induced pluripotent stem cells (hiPSCs) is crucial for stem cell applications. Although …

The defining features of embryonic stem cells (ESCs) are their self-renewing and pluripotent
capacities. Indeed, the ability to give rise into all cell types within the organism not only …