Clinical trials have demonstrated the capacity for dopamine neurons, transplanted
ectopically into the striatum, to structurally integrate, restore dopamine transmission, and …

Human fetal midbrain tissue grafting has provided proof-of-concept for dopamine cell
replacement therapy (CRT) in Parkinson's disease (PD). However, limited tissue availability …

Aim: The objective of this study was to compare the efficacy of different recombinant,
commercially available Wingless/Int‐1 (WNTs) with regard to WNT/β‐catenin signalling …

During development of the central nervous system, trophic, together with genetic, cues
dictate the balance between cellular proliferation and differentiation. Subsequent to the birth …

Wnt1 and-5a have been shown to modulate the proliferation and differentiation of midbrain
dopaminergic (DA) neurons. However, it is not known whether other Wnts or which Frizzled …

Background: The ancient and highly evolutionarily conserved Wnt signaling pathway is
critical in nearly all tissues and organs for an organism to develop normally from embryo …

Abstract Aim: The Wnt/Frizzled signalling pathway is highly conserved through evolution.
Frizzled, the receptors for Wnts, have the topology of seven transmembrane spanning …

The dopamine D2 receptor (D2R) plays an important role in mesencephalic dopaminergic
neuronal development, particularly coupled with extracellular signal-regulated kinase (ERK) …

Neural induction of midbrain dopaminergic (DA) neurons from embryonic stem (ES) cells
can be achieved by culturing them on a bone marrow‐derived stromal cell line, PA6, which …

Lrp6 is generally described as a receptor required for signal transduction in the Wnt/β‐
catenin pathway. Wnt5a, however, is a Wnt ligand that usually does not activate Wnt/β …