The newer progestogens desogestrel, norgestimate, gestodene, dienogest and nomegestrol
share the common property of having weak or no androgenic effects, but there is great …

There are large inter-and intra-individual variations in the serum concentrations of natural
and synthetic sex steroids irrespective of the route of administration. Oral ingestion of …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

Objective: To test whether use of combined oral contraceptives containing third generation
progestogens is associated with altered risk of venous thromboembolism. Design: Matched …

Much of P450 research has always been done with the view of appUcation to humans, even
when done with experimental animals and microorganisms. Research with the human …

A series of 21 different 4-substituted 2, 6-dimethyl-3-(alkoxycarbonyl)-l, 4-dihydropyridines
was considered with regard to oxidation to pyridine derivatives by human liver microsomal …

A series of 17a-acetylenic steroids was examined with regard to ability to inactivate human
liver microsomal cytochrome P-450 (P-450) IIIA4, an enzyme involvedin the oxidation of a …

The composition and use of Oral contraceptives (OCs) have Changed since their
cardiovascular side-effects were established 20 years ago. This report describes the risk of …

Abstract 17α-Ethinylestradiol (EE) is widely used as the estrogenic component of oral
contraceptives (OC). In vitro and in vivo metabolism studies indicate that EE is extensively …

Abstract 17 α-Ethynylestradiol is extensively sulfated but the sulfate is thought to primarily be
a storage form of this estrogen. 2-Hydroxylation is clearly the major oxidative reaction, and …