Introduction: Physiological pH and chemical pKa are two sides of the same coin in defining
the ionization of a drug in the human body. The Henderson-Hasselbalch equation and pH …

Background: Proton pump inhibitors (PPIs) are one of the most widely used drugs worldwide
and are overprescribed in patients with cancer; there is increasing evidence of their effects …

Background Proton-pump-inhibitors (PPIs) are frequently prescribed for the management of
anticancer drug-related gastrointestinal symptoms. Palbociclib is a weak base with pH …

Purpose Due to polypharmacy and the rising popularity of complementary and alternative
medicines (CAM), oncology patients are particularly at risk of drug–drug interactions (DDI) or …

Aims Proton pump inhibitors (PPIs) are often prescribed to prevent or treat gastrointestinal
disease. Whether the combination of systemic anti‐tumour therapy and PPIs leads to poor …

Abstract Introduction Approximately 20–33% of all cancer patients are treated with acid-
reducing agents (ARAs), most commonly proton pump inhibitors (PPIs), to reduce …

Introduction: Worldwide, the annual expenditure on anticancer drugs is grossly calculated to
be in the order of US 100billion,andisexpectedtoescalateupto 150 billion by 2020. It is …

New concepts and drugs have revolutionized medical treatment for cancers. These drugs,
which are very expensive and usually well tolerated, have dramatically improved cancer …

We performed a systematic review and meta-analysis to evaluate the role of gastric acid
suppressant use on outcomes of tyrosine kinase inhibitors (TKIs) and oral chemotherapy …

Gefitinib and erlotinib are the first-line tyrosine kinase inhibitors (TKI) for advanced non-
small-cell lung cancer. However, co-administration of either drug with proton pump inhibitors …